2002, Number 1
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Gac Med Mex 2002; 138 (1)
New Concepts in the Biology of Acute Myeloid Leukemia.
Montesinos JJ, Mayani H
Language: Spanish
References: 47
Page: 67-76
PDF size: 99.55 Kb.
ABSTRACT
During the last 20 years, several concepts regarding the biology of acute myeloid leukemia (AML) have changed in a profound manner. This has been mainly due to significant advances in the identification, purification and characterization of the primitive hematopoietic cells -including stem and progenitor cells- in which this disorder originates. In the present review article, we discuss some of these new concepts and their relevance in the treatment of AML.
REFERENCES
Löwenberg B, Downing JR, Burnett A. Acute myeloid leukemia. N Engl J Med 1999;341:1051-1062.
Kosary CL, Ries LAG, Miller BA, Hankey BF, Edwards BK, eds. SEER cancer statistics review, 1973-1992: tables and graphs. Bethesda, Md.: National Cancer Institute, 1995. (NIH publication no. 96-2789).
Registro Histopatológico de Neoplasias en México. Dirección General de Epidemiología, Secretaría de Salud. 1998.
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C. Proposed revised criteria for the classification of acute myeloid leukemia: a report of the French-American-British Cooperative Group. Ann Intern Med 1985;103:620-625.
Till JE, McCulloch EA. Hemopoietic stem cell differentiation. Biochem Biophys Acta 1980;605:431-459.
Trentin J. Hemapoietic microenvironments. In: Tavassoli M (ed). Handbook of the Hemapoietic Microenvironment. Humana press: Clifone, PP 1-86,1989.
Nicola NA. Hemapoietic cell growth factors and their receptors. Annu Rev Biochem 1989;58:45-77.
McCulloch EA. Stem cell renewal and determination during clonal expansion in normal and leukemic hemopoiesis. Cell Prolif 1993;26:399-425.
Berardi A, Wang A, Levine J, Lopez P, Scadden D. Functional isolation and characterization of human hematopoietic stem cells. Science 1995;267:104-108.
Ogawa M, Porter P, Nakahata T. Renewal and commitment to differentiation of hemopoietic stem cells: an interpretative review. Blood 1983;61:823-829.
Healy L, May G, Gale K, Grosveld F, Greaves M, Enver T. The stem cell antigen CD34 functions as regulator of hemopoietic cell adhesion. Proc Natl Acad Sci USA 1995;92:12240-12244.
Mayani H, Landsdorp P. Thy-1 expression is linked to functional properties of primitive hematopoietic progenitor cells from human umbilical cord blood. Blood 1994;83:2410-2417.
Terstappen LWMM, Huang S, Safford M, Landsdorp P, Loken MR. Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells. Blood 1991;77:1218-1227.
Kamel-Reid S, Dick JE. Engrafment of immune-deficient mice with human hematopoietic stem cells. Science 1988;242:1706-1709.
Dick JE. Normal and leukemic human stem cells assayed in SCID mice. Semin lmmunol 1996;8:197-206.
Sutherland HJ, Lansdorp PM, Henkelman DH, Eaves AC, Eaves CJ. Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers. Proc Natl Acad Sci USA 1990;87:3584-3588.
Cashman JD, Lapidot T, Wang JC, Doedens M, Shultz LD, Landsdorp P, Dick JE, Eaves CJ. Kinetics evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice. Blood 1997;89:4307-4316.
Metcalf D. Hemopoietic colonies. In vitro cloning of normal and leukemic cells. Berlin, Heidelberg:Springer-Verlag, 227,1977.
Griffin JD, Lowenberg B. Clonogenic cells in acute myeloblastic leukemia. Blood 1986;68:1185-1195.
Fialkow PJ, Singer JW, Adamson JW, Vaidya K, Dow LW, Ochs J, Moohr JW. Acute nonlymphocytic leukemia: Heterogeneity of stem cell origin. Blood 1981;57:1068-1073.
Haase D, Feuring-Buske M, Konemann S. Evidence for malignant transformation in acute myeloid leukemia at the level of early hematopoietic stem cells by cytogenetic analysis of CD34+ subpopulations. Blood 1995;86:2906-2911.
Mehrotra B, George TI, Kavanau K. Cytogenetically aberrant cells in the stem cell compartment (CD34+ Lin-) in acute myeloid leukemia. Blood 1995;86:1139-1145.
Dick JE. Assays for human leukemic stem cells. American Society of Hematology Education Program Book 1999:112-119.
Turhan AG, Lemoine FM, Debert C. Highly purified primitive hematopoietic stem cells are PML-RARA negative and generate monoclonal progenitors in acute promyelocytic leukemia. Blood 1995;85:2154-2161.
Clarkson B, Fried J, Strife A, Sakai Y, Ota K, Ohkita T. Studies of cellular proliferation in human leukemia. III. Behavior of leukemic cells in three adults with acute leukemia given continous infusions of 3H-thymidine for 8 or 10 days. Cancer 1970;25:1237-1260.
Minden MD, Till JE, McCulloch EA. Proliferative state of blast cell progenitors in acute myeloblastic leukemia (AM L). Blood 1978;52:592-600.
Coulombel L, Eaves C, Kalousek D, Gupta C, Eaves AC. Long-term marrow culture of cells from patients with acute myelogenous leukemia. J Clin lnvest 1985;75:961-969.
Mayani H, Shen S, Guilbert U, Clark SC, Sych I, Janowska-Wieczoreck A. Effect of rhCSF-1 on human hemopoiesis in long-term cultures from patients with acute myelogenous leukemia. Leukemia 1991;5:8-13.
Löwenberg B, Bauman JGJ. Further results in understanding the subpopulation structure in AML: Clonogenic cells and their progeny identified by differentiation markers. Blood 1985;66:1225-1232.
Sutherland HJ, Blair A, Zapf RW. Characterization of a hierarchy in human acute myeloid leukemia progenitor cells. Blood 1996;87:4754-4761.
Blair A, Hogge DE, Ailles LE, Lansdorp PM, Sutherland HJ. Lack of expression of Thy-1 (CD90) on acute myeloid leukaemia cells with long-term proliferative ability in vitro and in vivo. Blood 1997;89:3104-3112.
Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Cáceres-Cortés J, Minden M, Paterson B, Caligiun MA, Dick JE. A cell initiating LMA after transplantation into SCID mice. Nature 1994;367:645-648.
Costello RT, Mallet F, Gaugler B, Sainty D, Arnoulet C, Gastaut J-A, Olive D. Human acute myeloid leukemia CD34+CD38- progenitor cells have decreased sensitivity to chemotherapy and Fas-induced apoptosis, reduced immunogenicity and impaired dendritic cell transformation capacities. Cancer Res 2000;60:4403-4411.
Craig W, Kay R, Cutler RB, Lansdorp PM. Expression of Thy-1 on human hematopoietic progenitor cells. J Exp Med 1993;177:1331-1338.
Papayannopoulou T, Brice M, Broudy VC, Zsebo KM. Isolation of c-kit receptor-expressing cells from bone marrow, peripheral blood, and fetal liver: functional properties and composite antigenic profile. Blood 1991;78:1403-1412.
Blair A, Sutherland HJ. Primitive acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo lack surface expression of c-kit (CD117). Exp Hematol 2000;28:660-671.
Dexter TM, Allen TD, Lajtha LG. Conditions controlling the proliferation of hematopoietic stem cells in vitro. J Cell Physiol 1977;91:335-344.
Mayani H, Guilbert U, Clark SC, Belch AR, Janowska-Wieczorek A. Composition and functional integrity of the in vitro hemopoietic microenvironment in acute myelogenous leukemia: effect of macrophage colony-stimulating factor. Exp Hematol 1992;20:1077-1084.
Chang J, Morgenstern G, Deakin D, Testa NG, Dexter TM. The use of bone marrow cells grown in LTC for autologous BMT in acute myeloid leukemia: an up date. Bone Marrow Transplant 1989;4:2-11.
Montesinos JJ, Flores P, Flores E, Martinez G, Mayani H. In vitro proliferation and expansion of human hematopoietic progenitor cells from normal subjects and patients with hematologic neoplasias. Exp Hematol 2000;28:95a.
Terpstra W, Prins A, Ploemacher RE, Wognum BW, Wagemater G, Lówenberg B, Wielenga JJ. Long-term leukemia-initiating capacity of a CD34- subpopulation of acute myeloid leukemia. Blood 1996;87:2187-2194.
Bhatia M, Bonnet D, Murdoch B, Gan OI, Dick JE. A newly discovered class of human hematopoietic cells with SCID-repopulating activity. Nature Med 1998; 4:1038-1045.
Grignani F, Valtien M, Gabbianelli M, Gelmetti V, Botta R, Luchefti L, Masella B, Morsilli O, Pelosi E, Samoggia P, Pelicci PG, Peschle C. PMLIRAR alpha fusion protein expression in normal human hematopoietic progenitors dictates myeloid commitment and the promyelocytic phenotype. Blood 2000;96:1531-1537.
Hromas R, Shopnick R, Jumean HG, Bowers C, Varella-Garcia M, Richkind K. A novel syndrome of radiation-associated acute myeloid leukemia involving AML1 gene translocations. Blood 2000;95:4011-4013.
Schmetzer HM, Braun S, Wiesner D, Duell T, Gerhartz HH, Mittermueller J. Gene rearrangements in bone marrow cells of patients with acute myelogenous leukemia. Acta Haematol 2000;103:125-134.
Cline MJ. The molecular basis of leukemia. N Engl J Med 1994;330:328-336.
Mayani H. Composition and function of the hemopoietic microenvironment in human myeloid leukemia. Leukemia 1996;10:1041-1047.