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ISSN 1561-3119 (Electronic)

2017, Number 2

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Rev Cubana Pediatr 2017; 89 (2)

Open randomized study of children with acute exacerbation of asthma and treated with inhaled steroids

Kassisse E, Prada L, Salazar I, García H, Kassisse J

Language: Spanish
References: 35
Page: 165-176
PDF size: 305.58 Kb.


ABSTRACT

Introduction: primary therapy for acute asthma attacks includes administration of oxygen, use of inhaled β2-agonists and of systemic steroids. The advantages of the use of inhaled steroids will be rapid onset of action and good safety profile in comparison with the systemic steroids.
Objective: to evaluate the usefulness of inhaled corticoids in treating acute asthma attacks in children older than 2 years.
Methods: prospective, cross-sectional, experimental, randomized study of clinical effectiveness was conducted; the selection of patients was based on a random number table and included three groups: the first received standard treatment, the second one replaced systemic steroid by the inhaled one and the third combined standard treatment and inhaled steroid. The statistical analysis included ANOVA and Chi-square with p ‹ 0.05 as significant value.
Results: one hundred and sixty five patients were studied and the three treatment groups improved their initial severity scale. The patients who received inhaled steroids added to the standard therapy showed 73 % possibilities of non hospitalization, 27 % possibilities of reduced risk of hospitalization and 8 hospitalizations were prevented per every 100 patients treated with the combination.
Conclusions: inhaled steroids were therapeutically equivalent to systemic steroids.


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