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2001, Number 6

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Gac Med Mex 2001; 137 (6)

Análisis de HLA-DR en pacientes mexicanos con pénfigo.

Vega-Memije ME, Sáez de Ocariz-Gutiérrez MM, Cortés-Franco R, Domínguez-Soto L, Granados-Arriola J

Language: Spanish
References: 26
Page: 535-540
PDF size: 168.63 Kb.


ABSTRACT

Pemphigus are a group of bullous skin disorders histologically characterized by intraepidermal acantholytic and circulating antibodies blisters due to directed against the cellular surface of keratinocytes. In Mexican patients with pemphigus, HLA antigens have not been studied as they have been for other populations; for this reason, a comparative, prospective, transversal and observational study has been done with 25 patients, 18 with pemphigus vulgaris and the other seven with pemphigus foliaceus. DNA was extracted by the salting-out method and HLA-DR was determined by amplification with PCR and allele-specific oligonucleotides (ASO). Results: HLA-DR14 (DR6) is more common in patients with pemphigus vulgaris than in the healthy population, which corroborates with previous reports. On the other hand, as reported we also found that HLA-DR1 in Mexican population represents a higher risk for pemphigus foliaceus.


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