Ramírez-Mares AL, Morales-Sánchez MA, Peralta-Pedrero ML, Olguín-García MG, Jurado-Santa Cruz F

Language: Spanish
References: 23
Page: 5-9
PDF size: 208.84 Kb.

ABSTRACT

Introduction: Acne is a chronic inflammatory disease of the pilosebaceous unit, which affects 9.4% of the adolescent population worldwide. Insulin-like growth factor-1 (IGF-1) is implicated in the pathophysiology of acne, especially the inflammatory type. Objective: To determine and compare IGF-1 levels in patients with mild and severe inflammatory acne. Material and methods: A comparative cross-sectional study was carried out from May to July at a referral skin center. Patients aged 12 to 25 years with diagnosis of mild and severe inflammatory acne were recruited and serum IGF-1 was measured in both groups. Results: One hundred and three patients were recruited, 50 with mild inflammatory acne (52% men and 48% women) and 53 with severe acne (52.8% men and 47.2% women). Body mass index (BMI) was higher in the group of severe acne (p ‹ 0.022). No differences were found on average IGF-1 levels among both groups, 282.26 µU/mL versus 286.62 µU/mL, respectively. Conclusions: IGF-1 levels in individuals with mild and severe acne do not present statistically significant differences directly proportional to the severity of acne.

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