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ISSN 1561-2996 (Electronic)
ISSN 0864-0289 (Print)

2016, Number 4

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Rev Cubana Hematol Inmunol Hemoter 2016; 32 (4)

Longitudinal ecocardiographic assesment in patients with acute lymphoid leukemia that received anthracyclines during childhood

González OA, Machín GS, Arencibia NA, Collazo AJ, Rivera KC, Bravo POL, Menéndez VA, Serrano MJ, Gil AM, Lam DRM, Svarch E

Language: Spanish
References: 33
Page: 470-482
PDF size: 145.23 Kb.


ABSTRACT

Introduction: Cancer therapy could cause frequent cardiac toxicity, so we decided to perform an echocardiographic longitudinal study of the late effects caused by anthracyclines administration in patients that were treated for acute lymphoid leukemia during childhood.
Methods: All the patients admitted in the Pediatric Service of Institute of Hematology and Immunology, with acute lymphoid leukemia since april 2002 until february 2015 and that have at least two echocardiographic studies after finishing therapy. A complete physical exammination was performed to all of them and the cumulative dose of anthracyclines received was calculated and also time until evaluation. From the echocardiograms were taken the measurements of left auricle, right ventricle, ejection fraction and shortening fraction.
Results: the main findings were signs of late subclinical cardiotoxicity with a mean of 9 years after therapy completion and there were no sex predominance. In the first echocardiogram performed three years after stopping therapy there were more alterations in the measures of left auricle and right ventricle. The studies were repeated every three years and in the third one there were more alterations in ejection fraction and shortening fraction and there also were a statiscally significative relation between cumulative anthracyclines doses and echocardiographic findings.
Conclusions: There were found subclinical cardiac dysfunction that increases as time goes by.


REFERENCES

  1. Kaushansky K, Lichtman MA, Beutler E, Kipps TJ, Seligsohn U, Prchal JT. Williams Hematology. 8 ed. New York: Mc Graw-Hill; 2010.

  2. Hoffman R, Benz EJ, Silberstein LE, Heslop HE, Weitz JI, Anastasi J. Hematology. Basic Principles and Practice. 6 ed. Philadelphia: Elsevier; 2013. p.935-51.

  3. Whitlock JA, Gaynon PS. Acute Lymphoblastic Leukemia in Children. En: Greer JP, et al, editors. Wintrobe's clinical hematology. 12 ed. Philadelphia:Lippincott Williams & Wilkins; 2009. p.1890-911.

  4. Khakoo AY, Liu PP, Force T, Lopez-Berestein G, Jones LW, Schneider J, et al. Cardiotoxicity due to cancer therapy. Tex Heart Inst J. 2011;38(3):253-6.

  5. Comité de Medicamentos de la Asociación Española de Pediatría. Pediamécum. Antraciclinas. Edición 2015. (Citado en 14/07/2015). Disponible en: http://www.pediamecum.es .

  6. Salazar-Mendiguchía J, González-Costello J, Roca J, Ariza-Solé A, Manito N, Cequier Á. Miocardiopatía inducida por antraciclinas: conocimientos moleculares básicos para el cardiólogo. Arch Cardiol Mex. 2014;84(3):21-32.

  7. Pérez C, Agustí MA, Tornos P. Cardiotoxicidad tardía inducida por antraciclinas. Med Clin. 2009;133(8):311-3.

  8. Cuns DI, Lagrotta PI. Toxicidad a largo plazo del tratamiento de LLA pediátrica. Hematolología. 2013;17(3):223-30.

  9. Ruggiero A, Ridola V, Puma N, Molinari F, Coccia P, De Rosa G, et al. Anthracycline cardiotoxicity in childhood. Pediatr Hematol Oncol. 2008;25(4):261-81.

  10. Lipshultz SE, Alvarez JA, Scully RE. Anthracycline associated cardiotoxicity in survivors of childhood cancer. Heart. 2008;94(4):525-33.

  11. Hurtado SN, Mejía AMC, Sanabria AC. Cardiotoxicidad por quimioterapia. Un enfoque práctico para el clínico. Insuf Card. 2011;6(3):131-41.

  12. Parma G, Lluberas N, Castillo C, Ormaechea G. Quimioterápicos y Cardiotoxicidad: un enfoque actual y práctico para el clínico de una disciplina en pleno desarrollo. Arch Med Interna. 2013;35(2):37-44.

  13. Creutzig U, Diekamp S, Zimmermann M, Reinhardt D. Longitudinal evaluation of early and late anthracycline cardiotoxicity in children with AML. Pediatr Blood Cancer. 2007;48(7):651-62.

  14. Fulbright JM. Review of cardiotoxicity in pediatric cancer patients: during and after therapy. Cardiol Res Pract. 2011; 2011:942-90. doi: 10.4061/2011/942090.

  15. Rathe M, Carlsen NL, Oxhoj H. Late cardiac effects of anthracycline containing therapy for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2007;48(7):663-7.

  16. Rathe M, Carlsen NL, Oxhoj H, Nielsen G. Long-term cardiac follow-up of children treated with anthracycline doses of 300 mg/m2 or less for acute lymphoblastic leukemia. Pediatr Blood Cancer. 2010;54(3):444-8.

  17. Uchikoba Y, Fukazawa R, Ohkubo T, Maeda M, Ogawa S. Early detection of subclinical anthracyclinecardiotoxicity on the basis of QT dispersion. J Nihon Med Sch. 2010;77(5):234-43.

  18. Adams MJ, Lipshultz SE. Pathophysiology of anthracycline- and radiationassociated cardiomyopathies: implications for screening and prevention. Pediatr Blood Cancer. 2005;44(7):600-6.

  19. Tolba KA, Deliargyris EN. Cardiotoxicity of cancer therapy. Cancer Invest. 1999;17(6):408-22.

  20. Lai WW, Geva T, Shirali GS, Frommelt PC, Humes RA, Brook MM, et al. Guidelines and standards for performance of a pediatric echocardiogram: a report from the Task Force of the Pediatric Council of the American Society of Echocardiography. J Am Soc Echocardiogr. 2006 Dec; 19(12):1413-30.

  21. Lopez L, Colan SD, Frommelt PC, Ensing GJ, Kendall K, Younoszai AK, et al. Recommendations for quantification methods during the performance of a pediatric echocardiogram: a report from the Pediatric Measurements Writing Group of the American Society of Echocardiography Pediatric and Congenital Heart Disease Council. J Am Soc Echocardiogr. 2010 May;23(5):465-95;576-7.

  22. Abosoudah I, Greenberg ML, Ness KK, Benson L, Nathan PC. Echocardiographic surveillance for asymptomatic late-onset anthracycline cardiomyopathy in childhood cancer survivors. Pediatr Blood Cancer. 2011 Sep;57(3):467-72.

  23. Kaski JP, Daubeney PE. Normalization of echocardiographically derived pediatric cardiac dimensions to body surface area: time for a standardized approach. Eur J Echocardiogr. 2009 Jan;10(1):44-5.

  24. Landier W, Bhatia S, Eshelman DA, Forte KJ, Sweeney T, Hester AL, et al. Development of risk-based guidelines for pediatric cancer survivors: the Children's Oncology Group Long-Term Follow-Up Guidelines from the Children's Oncology Group Late Effects Committee and Nursing Discipline. J Clin Oncol. 2004 Dec; 22(24):4979-90.

  25. Common Terminology Criteria for Adverse Events (CTCAE) and Common Toxicity Criteria (CTC). National Cancer Institute; 2010 Jun 14. (Citado en 2012 Feb 18). Disponible en: http://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03_2010-06-14.xls.

  26. Cedré Hernández T, Martínez Cárdenas L, García Caraballoso MB, González Díaz A, González Ojeda G, Castillo Villocht A. Cardiotoxicidad tardía por antraciclinas en pacientes tratados por leucemia linfoblástica aguda infantil. Acta Méd Centro. 2013;7(3):1-4.

  27. Cardinale D, Colombo A, Bacchiani G, Tedeschi I, Meroni CA, Veglia F, et al. Early Detection of Anthracycline Cardiotoxicity and Improvement With Heart Failure Therapy. Circulation. 2015;131:1981-8.

  28. Consenso de diagnóstico, prevención y tratamiento de la cardiotoxicidad por tratamiento médico del cáncer. Rev Argentina Cardiol. 2013;81(5):28-34.

  29. Ramjaun A, AlDuhaiby E, Ahmed S, Wang L, Yu E, Nathan PC, et al. Echocardiographic Detection of Cardiac Dysfunction in Childhood Cancer Survivors: How Long Is Screening Required? Pediatr Blood Cancer. 2015;62:2197-203.

  30. Essig S, Li O C, Hitzler J; Leissening W, Greenberg M, et al. Risk of late effects of treatment in children newly diagnosed with standard risk acute lymphoblastic leukaemia. A report of the childhood cancer study group lancet. Oncol. 2014 Jul;(8):841-51.

  31. Lipshultz SE, Sdsatakos P, Maguire M, Kamir R, Ross SW, Franco VI, et al. Cardiotoxicity and cardioprotection in childhood cancer. Acta Haematol 2014;132(3- 4):391-9.

  32. Govendor J, Loos B, Marais F, Englerechra M. Mitochondrial catastrophe during doxorubicin induced cardiotoxicity. A revision of the protective role of melatonin. J Clin Oncol. 2014;57(4):367-80.

  33. Conway L, Mccarthy AI, Landimer P, Closk RA. The prevention, detection and management of cardiac treatment induced cardiac toxicity. A meta review. BMC Cancer. 2015;15:366.




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