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2016, Number 4

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Rev Cubana Hematol Inmunol Hemoter 2016; 32 (4)

Main immunomodulatory and anti-inflamatory properties of phycobiliproteins C-phycocyanin

Díaz DG, Marsán SV, del Valle PLO

Language: Spanish
References: 27
Page: 447-454
PDF size: 91.16 Kb.


ABSTRACT

Phycobiliproteins are water-soluble proteins that function as accessory photosynthetic pigments in different organisms such as cyanobacteria, red algae and cryptomonads. In the blue-green algae Spirulina platensis one of the most abundant phycobiliproteins is the C-phycocyanin, which has three phycocyanobilin chromophores linked through a thioether bond to specific cysteine. The phycocyanobilin is a linear tetrapyrrole associated with solar energy absorption in these organisms. The C-phycocyanin has been used in several biomedical researches as a biomarker, for their fluorescence properties, and as a possible therapeutic agent for the treatment of diseases associated with oxidative stress for its antioxidant, antiinflammatory and immunomodulatory properties. It has been shown that this protein increases the release of interferon gamma in peripheral blood mononuclear cells, and modulates the production of inflammatory cytokines such as tumor necrosis factor among others. Furthermore it has been found that the C-phycocyanin has immunomodulatory effect on cytokines that enhance the activation of immune cells, such as IL-6 and IL-1β, and the regulation of about 190 genes involved in immunity.


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