medigraphic.com

2017, Number S1

<< Back Next >>

Rev Med Inst Mex Seguro Soc 2017; 55 (S1)

Five-year survival analysis in patients with penile cancer

Montiel-Jarquín ÄJ, Contreras-Díaz AJ, Vázquez-Cruz E, Chopin-Gazga MA, Romero-Figueroa MS, Etchegaray-Morales I, Alvarado-Ortega I

Language: Spanish
References: 33
Page: 34-43
PDF size: 322.11 Kb.


ABSTRACT

Background: Short-term survival of penile cancer is poor. The objective was to describe the 5-years penile cancer survival.
Methods: Retrospective cohort study. We included patients with penile cancer managed surgically from 2010 to 2014. Descriptive statistics were used for socio-demographic variables and the Kaplan-Meier estimator for survival function.
Results: We studied 22 patients with a mean age of 64.95 years and a time of evolution of 25 months after the diagnosis. 68.2% of patients smoked or had human papillomavirus (HPV); they all presented phimosis; 72.7% had pain in the penis and the groin area; 81.8% had palpable lymph nodes and 45.5% lesions ≥ 3 cm; 86.3% were diagnosed in clinical stage IIIa. 59.1% underwent partial penectomy and 86.4% had squamous cell variety. 40.9% of patients died six months after the surgery. 66% of the smokers presented metastasis; all of the patients that smoked and had HPV infection had neurovascular invasion and died; 83.3% of the patients (n = 6) who underwent partial penectomy and positive lymph node dissection due to metastases died. The 5-years mortality of patients with penile cancer was 40.9%.
Conclusion:Tobacco use and HPV increase morbidity and mortality in patients with penile cancer; lesions greater than 5 cm are more common in smokers. The size of the lesion increases with the delay in treatment.


REFERENCES

  1. Pettaway C, Lynch D Jr, Davis D. Tumors of the penis. En: Wein AJ, Kavoussi LR, Novick AC, et al., (eds.) Campbell-Walsh Urology 10th Edition. Philadelphia: Saunders; 2011. pp. 959-992.

  2. Pow-Sang MR, Ferreria U, Pow-Sang JM, Nardi AC, Destefano V. Epidemiology and natural history of penile cancer. Urology. 2010; 76(2 Suppl 1):S2-S6.

  3. Jiménez-Ríos MA, Ariza-Villaro P, Solares-Sánchez ME, Martínez-Cervera P. Factores pronósticos de mortalidad en cáncer de pene. Gac Med Oncol. 2011;10(4):191-6.

  4. Di Capua-Sacoto C, Luján-Marco S, Morales-Solchaga G, Budía-Alba A, Pontones-Moreno JL, Jiménez- Cruz JF. Cáncer de pene. Nuestra experiencia en 15 años. Actas Urol Esp. 2009;33(2):143-8.

  5. Madsen BS, van den Brule AJ, Jensen HL, Wohlfahrt J, Frisch M. Risk factors for squamous cell carcinoma of the penis--population-based case-control study in Denmark. Cancer Epidemiol Biomarkers Prev. 2008;17(10):2683-91.

  6. The National Comprehensive Cancer Network. Guidelines Penile Cancer Inc. 2012. Version 1. 2012.

  7. Lont AP, Kroon BK, Horenblas S, Gallee MP, Berkhof J, Meijer CJ, et al. Presence of high-risk human papillomavirus DNA in penile carcinoma predicts favorable outcome in survival. Int J Cancer. 2006;119(5):1078-81.

  8. Misra S, Chaturvedi A, Misra NC. Penile carcinoma: a challenge for the developing world. Lancet Oncol. 2004;5(4):240-7.

  9. Baroas DA, Chang SS. Penile cancer: clinical presentation, diagnosis, and staging. Urol Clin North Am. 2010;37(3):343-52.

  10. Cubilla AL, Reuter V, Velazquez E, Piris A, Saito S, Young RH. Histologic classification of penile carcinoma and its relation to outcome in 61 patients with primary resection. Int J Surg Pathol. 2001;9:111-20.

  11. Eble JN, Sauter G, Epstein JI, Sesterhenn IA. World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. Lyon: IARC Publishing; 2004: 281-290.

  12. Chaux A, Lezcano C, Cubilla AL, Tamboli P, Ro J, Ayala A. Comparison of subtypes of penile squamous cell carcinoma from high and low incidence geographical regions. Int J Surg Pathol. 2010 Aug;18(4):268-77.

  13. Chaux A, Velazquez EF, Algaba F, Ayala G, Cubilla AL. Developments in the pathology of penile squeamous cell carcinomas. Urology. 2010;76(2 Suppl 1):S7-S14.

  14. Leijte JA, Kirrander P, Antonini N, Windahl T, Horenblas S. Recurrence Patterns of Squamous Cell Carcinoma of the Penis: Recommendations for Follow- Up Based on a Two-Centre Analysis of 700 Patients. Eur Urol. 2008;54(1):161-8.

  15. Novara G, Galfano A, De Marco V, Artibani W, Ficarra V. Prognostic factors in squamous cell carcinoma of the penis. Nat Clin Pract Urol. 2007;4(3):140-6.

  16. Pandey D, Mahajan V, Kannan RR. Prognostic factors in node-positive carcinoma of the penis. J Surg Oncol. 2006;93(2):133-8.

  17. Broders AC. Squamous-cell epithelioma of the skin: a study of 256 cases. Ann Surg. 1921;73(2):141-60.

  18. Solsona E, Bahl A, Brandes SB, Dickerson D, Puras- Baez A, van Poppel H, et al. New developments in the treatment of localized penile cancer. Urology. 2010;76(2 Suppl 1):S36-S42.

  19. Bissada NK, Yakout HH, Fahmy WE, Gayed MS, Touijer AK, Greene GF, et al. Multi-institutional longterm experience with conservative surgery for invasive penile carcinoma. J Urol. 2003;169(2):500-2.

  20. Lont AP, Gallee MP, Meinhardt W, van Tinteren H, Horenblas S. Penis conserving treatment for T1 and T2 penile carcinoma: clinical implications of a local recurrence. J Urol. 2006;176(2):575-80.

  21. Smith Y, Hadway P, Ahmed S, Perry MJ, Corbishley CM, Watkin NA. Penile preserving surgery for male distal urethral carcinoma. BJU Int. 2007;100(1):82-7.

  22. Montiel-Jarquín AJ, Villagómez-Camargo R, Chopin- Gazga M, González-López A, Palmer-Márquez L, Rodríguez-Pérez F, et al. Cáncer de pene en etapas tempranas: expresión negativa de Metaloproteinasa- 9 en biopsia. Pren Med Arg. 2015;101(8):444-50.

  23. Korets R, Koppie TM, Snyder ME, Russo P. Partial penectomy for patients with squamous cell carcinoma of the penis: the Memorial Sloan-Kettering experience. Ann Surg Oncol. 2007;14(12):3614-9.

  24. Ficarra V, Akduman B, Bouchot O, Palou J, Tobias- Machado M. Prognostic factors in penile cancer. Urology. 2010;76(2 Suppl 1):S66-73.

  25. Lont AP, Besnard AP, Gallee MP, van Tinteren H, Horenblas S. A comparison of physical examination and imaging in determining the extent of primary penile carcinoma. BJU Int. 2003;91(6):493-5.

  26. Ornellas AA, Seixas AL, Marota A, Wisnescky A, Campos F, de Moraes JR. Surgical treatment of invasive squamous cell carcinoma of the penis: retrospective analysis of 350 cases. J Urol. 1994;151(5):1244-9.

  27. Pietrzak P, Corbishley C, Watkin N. Organ-sparing surgery for invasive penile cancer: early follow-up data. BJU Int. 2004;94(9):1253-7.

  28. Shindel AW, Mann MW, Lev RY, Sengelmann R, Petersen J, Hruza GJ, et al. Mohs micrographic surgery for penile cancer: management and long-term followup. J Urol. 2007;178(5):1980-5.

  29. Villagómez-Camargo R. Experiencia en el manejo del Cáncer de pene en el Hospital General Regional No. 36 del Instituto Mexicano del Seguro Social [tesis de Especialidad]. Puebla: UPAEP-IMSS; 2014.

  30. Horenblas S, van Tinteren H, Delemarre JF, Moonen LM, Lustig V, Kröger R. Squamous cell carcinoma of the penis: accuracy of tumor, nodes and metastasis classification system, and role of lymphangiography, computerized tomography scan and fine needle aspiration cytology. J Urol. 1991;146(5):1279-83.

  31. Scardino E, Villa G, Bonomo G, Matei DV, Verweij F, Rocco B, et al. Magnetic resonance imaging combined with artificial erection for local staging of penile cancer. Urology. 2004;63(6):1158-62.

  32. Minhas S, Kayes O, Hegarty P, Kumar P, Freeman A, Ralph D. What surgical resection margins are required to achieve oncological control in men with primary penile cancer? BJU Int. 2005;96(7):1040-3.

  33. Pontillo H, Fernández A, León H. Experiencia de 15 años en el manejo del cancer de pene. Rev Venez Oncol. 2011;23(1):26-33.




2020     |     www.medigraphic.com