medigraphic.com

2017, Number 2

<< Back Next >>

Rev Med Inst Mex Seguro Soc 2017; 55 (2)

Relation of red cell distribution width and mean platelet volume with the severity of preeclampsia

Viana-Rojas JJ, Rosas-Cabral A, Prieto-Macías J, Terrones-Saldívar MC, Arcos-Noguez P, Bermúdez- Gómez J, Martínez-Padilla LE, Sandoval-Valdez DA, Hernández GF, Serrano-Díaz LC

Language: Spanish
References: 30
Page: 176-181
PDF size: 274.15 Kb.


ABSTRACT

Background: It has been established a strong association between the red cell distribution width (RDW) and mean platelet volume (MPV) with hypertension in non-pregnant patients. However, few studies have been performed in patients with preeclampsia, yielding inconsistent results. Our aim is to evaluate the relationship between RDW and MPV with the severity of preeclampsia.
Methods: Analytic cross-sectional study. We include 64 patients with preeclampsia (26 mild, 38 severe) and 70 patients with normotensive pregnancy. Clinical data, sociodemographic characteristics and laboratory measures, including RDW and MPV, were recorded for each patient.
Results: Hemoglobin and platelet count measures were similar between groups. Preeclamptic patients had levels of RDW (14.7 ± 1.4 vs. 13.4 ± 0.7, p = 0.0001) and MPV (11.8 ± 2.4 vs. 11.0 ± 1.4, p = 0.03) more elevated than control group. Moreover, severe preeclamptic subgroup had more elevated levels of RDW (15.0 ± 1.6 vs. 14.0 ± 0.6, p = 0.001) and MPV (12.7 ± 2.8 vs. 10.8 ± 1.8, p = 0.01) in comparison with mild preeclamptic patients.
Conclusions: We demonstrate that RDW and MPV are accessible and inexpensive measures associated with the severity of preeclampsia.


REFERENCES

  1. ACOG Committee on Practice Bulletins Obstetrics. Diagnostic and management of preeclampsia and eclampsia. Obstet Gynecol. 2001;98:159-167.

  2. Sibai BM. Preeclampsia as a cause of preterm and late preterm (near-term) births. Semin Perinatol. 2006;30:16-19.

  3. Ananth CV, Vintzileos AM. Maternal-fetal conditions necessitating a medical intervention resulting in preterm birth. Am J Obstet Gynecol. 2006;195:1557-1563.

  4. Dabbah S, Hammerman H, Markiewicz W, Aronson D. Relation between red cell distribution width and clinical outcomes after acute myocardial infarction. Am J Cardiol. 2010;105(3):312-7.

  5. Gul M, Uyarel H, Ergelen M, Karacimen D, Ugur M, Turer A et al. The relationship between red blood cell distribution width and the clinical outcomes in non-ST elevation myocardial infarction and unstable angina pectoris: a 3-year follow-up. Coron Artery Dis. 2012;23(5):330-6.

  6. Vayá A, Hernández V, Rivera L, Hernández JL, Lago A, Espańa F, Bautista D. Red blood cell distribution width in patients with cryptogenic stroke. Clin Appl Thromb Hemost. 2015;21(3):241-5.

  7. Patel KV, Ferrucci L, Ershler WB, Longo DL, Guralnik JM. Red blood cell distribution width and the risk of death in middle-aged and older adults. Arch Intern Med. 2009;169(5):515-523.

  8. Sahin DY, Gür M, Elbasan Z, Özdoğru I, Uysal OK, Kivrak A et al. Mean platelet volume and extent and complexity of coronary artery disease in diabetic and nondiabetic patients with ST elevation myocardial infarction. Angiology. 2013;64(7):505-11.

  9. Tanindi A, Topal FE, Topal F, Celik B. Red cell distribution width in patients with prehypertension and hypertension. Blood Press. 2012;21(3):177-81.

  10. Ozcan F, Turak O, Durak A, Işleyen A, Uçar F, Giniş Z et al. Red cell distribution width and inflammation in patients with non-dipper hypertension. Blood Press. 2013;22(2):80-5.

  11. Varol E, Akcay S, Icli A, Yucel H, Ozkan E, Erdogan D, Ozaydin M. Mean platelet volume in patients with prehypertension and hypertension. Clin Hemorheol Microcirc. 2010;45(1):67-72.

  12. Inanc T, Kaya MG, Yarlioglues M, Ardic I, Ozdogru I, Dogan A et al. The mean platelet volume in patients with non-dipper hypertension compared to dippers and normotensives. Blood Press. 2010;19(2):81-5.

  13. Kurt RK, Aras Z, Silfeler DB, Kunt C, Islimye M, Kosar O. Relationship of red cell distribution width with the presence and severity of preeclampsia. Clin Appl Thromb Hemost. 2015;21(2):128-31.

  14. Abdullahi H, Osman A, Rayis DA, Gasim GI, Imam AM, Adam I. Red blood cell distribution width is not correlated with preeclampsia among pregnant Sudanese women. Diagnostic Pathology. 2014;9:29.

  15. Ceyhan T, Beyan C, Başer I, Kaptan K, Güngör S, Ifran A. The effect of pre-eclampsia on complete blood count, platelet count and mean platelet volume. Ann Hematol. 2006;85(5):320-2.

  16. Freitas LG, Alpoim PN, Komatsuzaki F, Carvalho M, Dusse LM. Preeclampsia: Are platelet count and indices useful for its prognostic? Hematology. 2013;18(6):360-4.

  17. ACOG Practice Bulletin. Diagnosis and management of preeclampsia and eclampsia. Int J Gynaecol Obstet. 2002;77(1):67-75.

  18. HJ Motulsky. Prism 5 Statistics Guide. 1Ş Ed. Graph- Pad Software Inc., San Diego CA, 2007.

  19. Tefferi A, Hanson CA, Inwards DJ. How to interpret and pursue an abnormal complete blood cell count in adults. Mayo Clin Proc. 2005;80:923-936.

  20. Huang YL, Hu ZD, Liu SJ, Sun Y, Qin Q, Qin BD et al. Prognostic value of red cell distribution width for patients with heart failure: A systematic review and meta-analysis of cohort studies. Plos One. 2014;9(8):e104861.

  21. Vayá A, Sarnago A, Fuster O, Alis R, Romagnoli M. Influence of inflammatory and lipidic parameters on red blood cell distribution width in a healthy population. Clin Hemorheol Microcirc. 2015;59(4):379-85.

  22. Denghani MR, Taghipour-Sani L, Rezaei Y, Rostami R. Diagnostic importance of admission platelet volume indices in patients with acute chest pain suggesting acute coronary syndrome. Indian Heart J. 2014;66(6):622-8.

  23. Martin JF, Trowbridge EA, Salmon G, Plumb J. The biological significance of platelet volume: Its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res. 1983;32:443-460.

  24. Giles H, Smith RE, Martin JF. Platelet glycoprotein IIb-IIIa and size are increased in acute myocardial infarction. Eur J Clin Invest. 1994;24:69-72.

  25. Pijnenborg R, Vercruysse L, Hanssens M. Fetalmaternal conflict, trophoblast invasion, preeclampsia, and the red queen. Hypertens Pregnancy. 2008;27:183-196.

  26. Hung TH, Burton GJ. Hypoxia and reoxygenation: A possible mechanism for placental oxidative stress in preeclampsia. Taiwan J Obstet Gynecol. 2006;45:189-200.

  27. LaMarca BD, Gilbert J, Granger JP. Recent progress toward the understanding of the pathopysiology of hypertension during preeclampsia. Hypertension. 2008;51:982-988.

  28. Kronborg CS, Gjedsted J, Vittinghus E, Hansen TK, Allen J, Knudsen UB. Longitudinal measurement of cytokines in pree-clamptic and normotensive pregnancies. Acta Obstet Gynecol Scand. 2011;90:791-796.

  29. Serin YS, Özcelik B, Bapbud M, Hüseyin K, Okur D, Erez R. Predictive value of tumonecrosis factor alpha (TNF-alpha) in preeclampsia. Euro Journ Obstet Gynecol. 2002;100:143-145.

  30. Xiao JP, Yin YX, Gao YF, Lau S, Shen F, Zhao M, Chen Q. The increased maternal serum levels of IL-6 are associated with the severity and onset of preeclampsia. Cytokine. 2012;60:856-860.




2020     |     www.medigraphic.com