2002, Number 4
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Rev Neurol Neurocir Psiquiat 2002; 35 (4)
Discoveries of cerebral perfusion with tomography by emission of unique photon, SPECT of brain. Experience at the Military Central Hospital
Sosa LCA, Turrubiates CE, Sosa GLE, Torres TAM
Language: Spanish
References: 62
Page: 183-202
PDF size: 753.65 Kb.
ABSTRACT
Objective. The known brain image test as tomography
by emission of photon unique SPECT of brain.
Method. A transversal study was carrier out to evaluate
the experience accumulated by the subsection of Nuclear
Medicine of the Mexican Military Central Hospital (HCM)
since the year 1992 to the 2000, in a group of 261 cases,
originating from the population of patient that they remitted
for their evaluation. Finding where 152 male and 109
female. Independent physicians revised the clinical readings.
They used a eight colors rainbow scale. Qualifying
them in: Black or blue as without perfusion, green or yellow
as hipoperfusion, violet or white as hiperperfusion;
consider abnormal bosses and orange as perfusion basal
or red as perfusion of activation; with the character of
normal. The SPECT brain images in the three cuts were
evaluated in axial, coronal and sagital projections divided
into right brain hemisphere and left brain hemisphere, in
specific anatomic brain places. Frontal lobes, temporal lobes,
parietal lobes, occipital lobes, cerebellums, ventricles,
thalamus, brain steam and limbic system were included.
Results. Two hundred and six cases with bosses of
abnormality in the perfusion, 18 were negative to the test
of SPECT cerebral and 37 excluded because technical
faults. The diagnoses corresponded: Epilepsy (idiopathic; 10 male and 4 female. Motor: 7 males and 5 females. Epilepsy:
8 males and 6 females). Brain cysticercosis: 5 male
and 3 females. Brain tumors: 3 male and 1 female. Stroke:
6 males and 6 females. Cranial trauma: 9 male and 7 female.
One male and 3 female with Alzheimer disease.
With not including diagnostic were 44 males and 36 females.
Ten male and 8 female were healthy. We find differentiates
significant among the two sexes in the perfusion of
both cerebral hemispheres and among the different cerebral
regions. It found the find of diasquisis of cerebellum
and the increase of perfusion compensatory of the lobules
of the other hemisphere. The righting clinical of the patient
is directly proportional to the best perfusion of the region
priory affected after of the processing. The left hemisphere
observed more affected in both sexes.
Conclusion. The technical one SPECT of brain marked
with Bicisate of tecnesio-99 metaestable (99mTc-ECD) as
a sure study and of high sensibility that permits to detect
alterations of the cerebral perfusion. Its employment is justifying
in patient with probable or sure diagnoses of neurological
diseases or psychiatric disorders, in spite of normal
or not conclusive studies of axial computed tomography,
nuclear magnetic resonance or electroencephalography.
SPECT of brain permits to define the existence and location
of brain alteration in patients with unknown symptomatology.
REFERENCES
Abdei-Dayem HM, Sadek SA, Kouris K, et al. Changes in cerebral perfusion after acute head injury: Comparison of CT with Tc-99m-HMPAO SPECT. Radiology 1987; 165: 221-6.
Sosa-Luna CA, Méndez G, Gutiérrez O. Análisis del índice ventrículo cerebral en tomografías axiales computadas de pacientes esquizofrénicos y su correlación con la escala de síntomas positivos y negativos para la esquizofrenia. Rev Sanid Milit Mex 1999; 53(2): 123-8.
Gray BG, Ichise M, Chung DG, et al. Technetium-99m-HMPAO SPECT in the evaluation of patients with a remote history of traumatic brain injury: A comparison with X-ray computed tomography. J Nucl Med 1992; 33: 52-8.
Seiderler M, Krappel W, Moser E, et al. Detection and quantification of chronic cerebrovascular disease: Comparison of MR imaging, SPECT, and CT. Radiology 1989; 170: 545-8.
Fayad PB, Lawrence MB. Single photon emission computed tomography in cerebrovascular disease. Stroke 1991; 22: 950- 4.
Davis S, Lichtenstein M, Kaye A, et al. A Single photon emission computed study of hypoperfusion after subarachnoid hemorrhage. Stroke 1990; 21: 252-9.
Carvalho PA, Schwart RB, Alexander III E, et al. Extracranial metastatic glioblastoma: Appeareance on thallium-201-chloride /technetium -99m-HMPAO SPECT images. J Nucl Med 1991; 32: 322-4.
Hollman BL, Sabah S, Tumeh. Single-Photon Emission Computed Tomography (SPECT) applications and potential. JAMA 1990; 263: 561-4.
Wagner HN Jr, Burns HD, Dannals RF. Imaging dopamine receptors in the human brain by positron tomography. Science 1983; 226: 1264-6.
Neirinckx RD, Burke FJ, Harrison RC, et al. The retention mechanism of technetium-99m-HMPAO: Intracellular reaction with glutatione. J Cereb Blood Flow Metab 1988; 8(suppl 1): S4-S12.
Islas-Marroquín J. Hacia las neurociencias moleculares. Rev Sanid Milit Mex 2000; 54(1): 41-3.
Schwarz J, Tatsch K, Amold G, et al. 123I-iodobenzamide- SPECT in 83 patients with de novo parkinsonism. Neurology 1993; 43(6): S17-S20.
Lenders KL, P Tyrrel P, et al. The nigrostriatal dopamine system assessed in vivo by positron emission tomography in healthy volunters subject and patients with Parkinson’s disease. Arch Neurol 1990; 47: 1290-8.
Kung H, Alavi A, Chang W, et al. In vivo SPECT imaging of CNS D2 dopamine receptors: Initial studies with iodine-123 IBZM in humans. J Nucl Med 1990; 31: 573-9.
Laulumaa V, Kuikka JT, Soininen H, et al. Imaging of D2 dopamine receptors of patients with Parkinson’s disease using single photon emission computed tomography and iodobenzamide I-123. Arch Neurol 1993; 50: 509-16.
Possitron emission tomography-a new approach to brain chemistry. Council of scienfific affairs: Report of the positron emission tomography panel. JAMA 1988; 260: 2704-10.
Baron JC, Lebrun-Grandie, Crouzel C, Mestelan G, Bousser MG. Noninvasive measurement of blood flow, oxygen consumption, and glucose utilization in the same brains regions in man by positron emission tomography: Concise communication. J Nucl Med 1982; 23: 391-9.
Sachs H, Russell JAG, Christman DR, et al. Positron emission tomographic studies on induced migraine. Lancet 1984; 465.
Fogelman, et al. An atlas of clinical nuclear medicine. Second edition. Editorial Mosby; 1996, UK.
Oku N, Matsumoto M, Hashikawa K, et al. Carbon dioxide reactivity by consecutive technetium-99m-HMPAO SPECT in patients with a chronically obstructed major cerebral artery. J Nucl Med 1994; 35: 32-40.
Ell PJ, Costa DC. The role of nuclear medicine in neurology and psychiatry. Curr Opin Neurol Neurosurg 1992; 5: 863-9.
Andreasen NC, Brain imaging: Aplications in psychiatry. Science 1988; 239: 1381-8.
Batjer HH, Devous MD Sr, Meyer YJ, et al. Cerebrovascular hemodynamics in arteriovenous malformation complicated by normal perfusion pressure breakthrough. Neurosurgery 1988; 22: 503-9.
Batjer HH, Devous MD Sr, Seibert GB, et al. Intracranial arteriovenous malfomation: Relationships between clinical and radiographic factors and ipsilateral steal severity. Neurosurgery 1988; 23: 322-8.
Haan J, van Kroonenburgh MJ, Algra PR, et al. Hereditary cerebral hemorrhage with amyloidosis-dutch type. Tc-99m HMPAO single photon emission computed tomography. Neuroradiology 1990; 32: 142-5.
Perani D, Vallar G, Cappa SF, et al. Aphasia and neglect after subcortical stroke. A clinical/cerebral perfusion correlation study. Brain 1987; 110: 1211-29.
Provenzale J. The current role of SPECT in imaging subdural hematoma. J Nucl Med 1992; 33: 248-50.
Rees JE, du Boulay GN, Bull JWD, et al. Regional cerebral blood flow in transient ischemic attacks. Lancet 1970; 2: 1210-3.
Maurer AH, Siegel JA, Comerota AJ, et al. SPECT quantification of cerebral ischemia before and after carotid endarterectomy. J Nucl Med 1990; 31: 1412-20.
Mountz JM, Modell JG, Foster NL, et al. Prognostication of recovery following stroke using the comparison of CT and technetium 99m HMPAO. J Nucl Med 1990; 31: 61-6.
Oder W, Goldenberg G, Prodeka 1, Deecke L. HM-PAO-SPECT in persistent vegetative state after head injury: Prognostic indicator of the likelihood of recovery? Intensive Care Med 1991; 17: 149-53.
Roper SN, Mena I, King WA, et al. An analysis of cerebral blood flow in acute closed-head injury using technetium-99-m- HMPAO SPECT and computed tomography. J Nucl Med 1991; 32: 1684-7.
Brazil P, Friedman A. Craniovascular studies in headache. A report and analysis of pulse volume tracings. Neurology 1956; 6: 96-102.
Simard D, Paulson OB. Cerebral vasomotor paralysis during migraine attack. Arch Neurol 1973; 29: 207-9.
Lauritzen M y Olesen J. Regional cerebral blood flow during migraine attacks by Xenon-133 inhalation and emission tomography. Brain 1984; 107: 447-61.
Lagréze HL, Dettmers C, Hartmann A. Abnormalities of interictal cerebral perfusion in classic but not common migraine. Stroke 1988; 19: 1108-11.
Rowe CC, Berkovic SF, Austin MC, et al. Visual and quantitative analysis of interictal SPECT with Technetium-99m-HMPAO in temporal lobe epilepsy. J Nucl Med 199 1; 32: 1688-94.
Newton MR, Austin MC, Chan JG, et al. Ictal SPECT using technetium- 99m-HMPAO: Methodsf or rapid preparation and optimal deployment of tracer during spontaneous seizures. J Nucl Med 1993; 34: 666-70.
Boller F, Lopez OC, Moosy J. Diagnosis of dementia: Clinicopathologic correlation. Neurology 1989; 39: 76.
Bonte FJ, Tintner R, Weiner MF, et al. Brain blood flow in the dementias: SPECT with histopathologic correlation. Radiology 1993; 186: 361-5.
Cohen MB, Grahain LS, Lake R, et al. Diagnosis of Alzheimer’s disease and multiinfarct dementia by tomographic imaging of lodine-123 IMP. J Nucl Med 1986; 27: 769-74.
Friedland RP. Alzheimer’s disease. Clinical features and differential diagnosis. Neurology 1993; 51(4): 545-51. 42a. Mendelow AD. Head injury: Pathology and pathophysiology. In: Swash M, Oxbury J, eds. Clinical neurology. London: Churchill Livingstone: 1991, p. 671-80.
Gemmell HG, Shaip PF, Evans NTS et al. Single photon emission tomography with 123-isopropyl-amphetamine in Alzheimer’s disease and multiinfarct dementia. Lancet 1984; 2: 1348.
Holman BL, Gibson RE, Hill TC, Eckelman WC, Albert M, Reba RC. Muscarinic acetylcholine receptors in Alzheimer’s disease: in vivo imaging with iodine 123-labeled 3-quinuclidinyl-4-iodobenzilate and emission tomography. JAMA 1985; 254: 3063-6.
McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer’s disease: Report of the NINCDS-ADRDA group under the auspices of the Dept. of Health and Human Task Force in Alzheimer’s disease. Neurology 1984; 34: 939-44.
Johnstone EC, Crow TJ, Frith CD, Husband J, Kreel L. Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet 1976; ii: 924-6.
Kung H, Pan S, Kung MP, et al. In vitro and in vivo evaluation of (1231)IBZM: A potential CNS D2 dopamine receptor imaging agent. J Nucl Med 1989; 30: 88-92.
Nasrallah HA, Mitchel Aj, Gur RC, Turetsky B, Cannon TD, Mosley PD. Brain and CSF volume differences in schizophrenic subjects. Am J Psychiatry, 1995; 152: 817-8.
Rossi A, Stratta O, Gallucci, M, Passariello R, Casaechia M. Quantification of corpus callosum and ventricles in schizophrenia with nuclear magnetic resonance imaging: A priori study. Am J Psychiatry 1989; 146: 99-101.
Biersack HJ, Coenen HH, Stocklin G, et al. Imaging of brain tumors with L-3-123I-lodo-(x-methyl) tyrosine and SPECT. J Nucl Med 1989; 30: 110-2.
Oriuchi N, Tanura M, Shibakazy T, et al. Clinical evaluation of thallium-201 SPECT in supratentorial gliomas: Relationship to histologic grade, prognosis and proliferative activities. J Nucl Med 1993; 34(20): 85-2089.
Johnson KA, Holman BL, Rosen J, et al. lodoanfetamine 123I single photon emission computed tomography is accurate in the diagnosis of Alzheimer’s disease. Arch Int Med 1990; 150: 752-6.
Langen KJ, Coenen HH, Roosen N, et al. SPECT studies of brain tumors with L-3-(123I)iodo-x-methyl tyrosinae: Comparison with PET, 124IMT and first clinical results. J Nucl Med 1990; 31: 281-6.
Nakano S, Kinoshita K, Jinnauchi S, et al. Dynamic SPECT with technetium-99m HMPAO in meningiomas. A comparison with iodine-123I IMP. J Nucl Med 1989; 30: 1101-5.
Holman BL, Garada B, Johnson KA, et al. A comparison of brain perfusion SPECT in cocaine abuse and AIDS dementia complex. J Nucl Med 1992; 33: 1312-5.
Pohl P, Vogl G, Fill H, et al. Single photon emission computed tomography in AIDS dementia complex. J Nucl Med 1988; 29: 1382-6.
Contreras C, Garnica R, Torres-Ruiz A, Arenas C, Marván ML, Lara H, Vázquez M. Visual evoked potentials in a sample of schizophrenic patients. Bol Estud Med Biol Mex 1990; 38: 22-8.
Sosa-Luna CA, Santiago VJ, De la Rosa V, Ninomiya A. Límites normales de latencias y amplitudes de los potenciales evocados en una población de adultos jóvenes mexicanos. Gaceta Médica de México 1995; 131(1): 109-11.
López-Ibor JA, Valdez MM, Pichot P. DSM-IV, Manual diagnóstico y estadístico de los trastornos mentales. Primera Edición, Barcelona. Ed. Masson, S.A.; 2000, p. 139-62 y 279-322.
Münch L, Ángeles E. Métodos y técnicas de investigación. Segunda Ed. México: Ed. Trillas; 2000.
Wayne WD. Bioestadística. Tercera y cuarta ediciones. México: Uteha Noriega Editores; 1991, p. 287-93 y 639-96.
Predaza L. Informática médica. Primera edición. México: Ed. Mc Graw-Hill Interamericana; 1998, p. 163-207.