Barros-Delgadillo JC, Pérez- Ramírez NP, Kava-Braverman A

Language: Spanish
References: 25
Page: 331-344
PDF size: 416.80 Kb.

ABSTRACT

Background: A premature elevation of serum progesterone level has been described in some cycles of IVF, despite adequate suppression of LH surge; this has been related to poor outcome that may vary depending on the ovarian response to stimulation.
Material and Methods: This is a retrospective controlled cohort study, which included 663 cycles where embryo transfer was achieved, from January 2011 to February 2015. Cycles were divided into Study groups depending on ovarian response to stimulation (Group I: ‹ 5, 5-10 and ›10 oocytes retrieved). For each group implantation, clinical pregnancy and ongoing pregnancy rates were studied depending on the level of progesterone using as a cutoff value ‹1.5 ng/mL and ≥ 1.5 ng/mL.
Results: Implantation, clinical pregnancy and ongoing pregnancy were significantly higher in Group III, regarding P4 level and whith P4 ‹1.5 ng/mL. Pregnancy rates were higher when P4 was ‹1.5 ng/mL in Groups II and III. No significant differences were found in the studied rates among Groups with P4 1.5 ng/mL.
Conclusion:The level of progesterone on the day of hCG application is a prognosis factor for FIV outcome, independent of ovarian response to stimulation

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