Gloria-Carrales AC, López-Jiménez FA

Language: Spanish
References: 42
Page: 177-183
PDF size: 495.42 Kb.

ABSTRACT

Background. The effect of general anesthesia on cerebral blood flow and metabolic cerebral rate may be pharmacologically managed to improve surgical and clinical course of patients with neurological diseases.
Objective. To evaluate neuroprotective mechanisms of continuous infusion of lidocaine plus anaesthetic drugs, in patients undergone to cerebral tumors resection as compared with anaesthetic drugs without lidocaine.
Method. We studied 36 exposed patients to cerebral tumors resection. Two training groups, each one became receiving different anesthetic drugs. First with a scheme of desfluorane, fentanyl and lidocaine, and the second with desfluorane and fentanyl as control group. The diminution in the consumption of anesthetic, cerebral tissue quality at the end of the surgery and anesthetic recovery was valued. The data with the tests statistical Ji-square and t-Student were analyzed, considering significant differences if p ‹ 0.05.
Results. with the use of lidocaine in continuous infusion were favorable, which is demonstrated by the following reasons: a) diminution in the inhaled consumption of anesthetic; b) diminution of the requirements of opioids; c) suitable cerebral protection, reflected in better tissue conditions; d) Anesthetic recovery in smaller time and better general conditions; e) Possibility of immediate postoperating neurological evaluation.
Conclusions. Neuroanesthetic management protocol that included lidocaine plus desflurane and fentanyl shows adequate brain protection. This research model is proposed for futures investigations.

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