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2016, Number 3

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Rev Cubana Hematol Inmunol Hemoter 2016; 32 (3)

Anti-C1q antibodies in patients with systemic lupus erythematosus in active phase

Guerreiro HAM, Villaescusa BR, Leyva RA, Merlín LJC, Arce HAA, Lam DRM

Language: Spanish
References: 21
Page: 388-393
PDF size: 52.01 Kb.


ABSTRACT

Introduction: Several studies have demonstrated the presence of anti-C1q antibodies in patients with systemic lupus erythematosus, although their participation in the pathogenesis of the disease is not fully clarified. The C1q plays a role in removing immune complexes and apoptotic cell debris, known source auntoantigens, and maintenance of the vascular endothelium. There is a wide variety of autoantibodies as antinuclear antibodies, anti double and single stranded DNA alongside the anti-C1q antibodies are used as diagnostic markers in patients with this disease.
Objective: To determine the prevalence of antibodies to C1q in the active phase of the disease.
Methods: The levels of anti-C1q antibodies were determined by an enzyme-linked immunosorbent assay (Orgentec) in the serum of 64 patients: 20 with systemic lupus erythematosus in active phase according to the index of activity of systemic lupus erythematosus, 44 with other rheumatic autoimmune diseases, and 30 healthy donors. The study was conducted in the period from 2013 to 2015.
Results: Anti C1q antibodies were detected in the sera of 8 of the 20 patients with lupus in active phase (40%), the presence of anti C1q antibody was demonstrated in nine of those with other rheumatologic diseases autoimmune (20.5%) and 4 of the healthy individuals (13.3%).
Conclusions: These results suggest the possible involvement of anti C1q antibodies in the existing damage in the active phase of the disease.


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