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2016, Number 4

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Rev Hosp Jua Mex 2016; 83 (4)

Estrategias para inhibir a HMGB1 liberado durante la sepsis

Rivera-Pérez RJ, Sevilla-González ML, Flores-Estrada JJ

Language: Spanish
References: 55
Page: 142-147
PDF size: 164.65 Kb.


ABSTRACT

HMGB1 (high mobility group box 1) was discovered as a non-histone chromosomal protein involved in several events related to DNA activity and gene transcription. It was later discovered that HMGB1 is a late phase mediator of the inflammatory response and several receptors have been identified that regulate its extracellular activity in multiple cellular processes. The intracellular and extracellular localization of HMGB1 plays significantly different roles in inflammation, injury, and cancer. In sepsis, HMGB1 is released late as a molecular pattern associated with cell damage (DAMP) and as a regulator of autophagy during the immune response. Numerous strategies to inhibit its release and activity have been studied. Here, we briefly review some evidence on its role and potential use as a potential therapeutic target in inflammatory diseases such as sepsis.


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