2017, Number 1
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Rev Mex Neuroci 2017; 18 (1)
Cerebral arteriovenous malformation treatment in the Hospital Juarez de Mexico
Melo-Guzmán G, Padilla-Vázquez F, Escobar-de la Garma VH, Mendizábal-Guerra R
Language: Spanish
References: 25
Page: 65-75
PDF size: 200.82 Kb.
ABSTRACT
Introduction: A cerebral arteriovenous
malformation (AVM) is a complex nidus of
abnormal vessels in the absence of capillaries,
which is generated during embryonic development.
This disease is the main cause of intracranial
hemorrhage in young patients, for which it is
necessary to provide an early diagnosis and
therapeutic methods .
Objective: To report our experience in managing
cerebral AVMs and to analyze the advantages of
embolization with subsequent surgical resection
of AVMs.
Methods: Retrospective study of 29 patients
with a diagnosis of AVM, to March 2010 to
March 2013, in the department of neurosurgery
at Hospital Juárez de México. We embolized the
AVMs of I-V grade of Spetzler Martin, performing
partial embolization to achieve complete occlusion
of the nidus and subsequently perform surgical
resection.
Results: Eight (27.5%) patients underwent
surgical resection without embolization and
21 (72.5%) patients underwent dual treatment
(embolization plus surgical resection). In all, 72
patients had a low-grade AVM, 62% received
bimodal treatment, observing decrease in transsurgical
bleeding (p=0.002). The remaining 38%
only underwent surgical resection with increased
risk of bleeding (p=0.029) .
Conclusions: Embolization of low-grade
AVM offers a safe resection with low morbidity.
Currently it is discussed the ideal treatment of highgrade
AVM, presenting a strong predisposition
to conservative management, while other groups
prefer medical management with the purpose of
reducing the risk of cumulative bleeding. Most of
AVMs can be curable in its entirety.
REFERENCES
Katsaridis V., Papagiannaki C., Aimar E, Curative embolization of cerebral arteriovenous malformations, with onyx® in 101 patients. Neuroradiology 2008; 50: 589-597.
Pierot L, Januel AC, Herbreteau D, Barreau X, Drouineau J, Berge J, et al. Endovascular treatment of brain arteriovenous malformations using onyx®; results of a prospective multicenter study. J Neuroradiol 2009: 36: 147-152.
Del Valle R, Zenteno M, Jaramillo J, Lee A, De Anda S. Definition of the key target volumen in radiosurgical management of arteriovenous malformations: a new dynamic concept base don angiographic circulation time. J Neurosurg 2008; 109: 41-50.
Kaspera W, Ladzinski P, Larysz P, Majchrzak H, Hebda A, Kopera M, et al. Transcranial color-coded Doppler assessment of cerebral arteriovenous malformation hemodynamics in patients treated surgically or with staged embolization. Clinical Neurology and Neurosurgery 2014; 116: 46-53.
Weber W, Kis B, Siekmann R, Kuehne D. Endovascular treatment of Intracranial Arteriovenous Malformations with Onyx®: technical aspects. AJNR Am J Neuroradiol 2007; 28: 371-377.
Abud DG, Riva R, Nakiri GS, Padovani F, Khawaldeh M, Mounayer C. Treatment of brain arteriovenous malformation by double arterial catheterization with simultaneous inyection of Onyx®: Retrospective series of 17 patients. AJNR Am J Neuroradiol 2011; 32: 152-158.
Mounayer C, Hammami N, Piotin M, Spelle L, Benndorf G, Kessler I, et al. Nidal Embolization of Brain Arteriovenous Malformations Using Onyx® in 94 Patients. AJNR Am J Neuroradiol 2007; 28: 518- 523.
Perez-Higueras A, Lopez RR, Tapia DQ. Endovascular treatment of cerebral AVM: our experience with Onyx®. Interv Neuroradiol 2005; 5: 11: 141-157.
Hofmeister C, Stapf C, Hartmann A, Sciacca RR, Mansmann U, terBrugge K, et al. Demographic, Morphological, and Clinical Characteristics of 1289 patients with brain arteriovenous malformation. Stroke 2000; 31: 1307-1310.
Panagiotopoulos V, Gizewski E, Asgari S, Regel J, Forsting M, Wanke I. Embolization of Intracranial Arteriovenous Malformations with Ethylene Vinyl Alcohol Copolymer (Onyx®). AJNR Am J Neuroradiol 2009; 30: 99-106.
Jayaraman MV, Marcellus ML, Hamilton S, Do HM, Campbell D, Chang SD, et al. Neurologic Complications of Arteriovenous Malformation Embolization Using Liquid Embolic Agents. AJNR Am J Neuroradiol 2008; 29: 242–246.
Viñuela F, Dion JE, Duckwiler G, Martin NA, Lylyk P, Fox A, et al. Combined endovascular embolization and surgery in the management of cerebral arteriovenous malformations: experience with 101 cases. J Neurosurg 1991; 75: 856-864.
Kader A, Young WL, Pile-Spellman J, Mast H, Sciacca RR, Mohr JP, et al. The influence of hemodynamic and anatomic factors on hemorrhage from cerebral arteriovenous malformations. Neurosurgery 1994; 34: 801-807.
Yamada S, Takagi Y, Nozaki K, Kikuta K, Hashimoto N. Risk factors for subsequent hemorrhage in patients with cerebral arteriovenous malformations. J Neurosurg 2007; 107: 965-972.
Spetzler RF, Martin NA. A proposed gradomg system for arteriovenous malformations. J Neurosurg 2008; 108: 186-193.
Mohr JP, Parides MK, Stapf C, Moquete E, Moy CS, Overbey JR, et al. Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial. Lancet 2014: 15: 614-621.
Kuhmonen J, Piippo A, Väärt K, Karatas A, Ishii K, Winkler P, et al. Early surgery for ruptured cerebral arteriovenous malformations. Acta Neurochir Suppl 2005; 94: 111-114.
Ondra SL, Troupp H, George ED, Schwab K. The natural history of symptomatic arteriovenous malformations of the brain: a 24 year follow up assessment. J Neurosurg 1990; 73: 387-391.
Muñoz F, Clavel P, Molet J, Castaño C, de Teresa S, Solivera J, et al. Current management of arteriovenous malformations. Retrospective study of 31 cases and literature review. Neurocirugía (Astur) 2007; 18: 394-405.
Han P, Ponce F, Spetzler RF. Intention to treat analysis of Spetzler Martin grades IV and V anrteriovenous malformation. Natural history and treatment paradigm. J Neurosurg 2003; 98: 3-7.
Chang SD, Marcellus ML, Marks MP, Levy RP, Do HM, Steinberg GK. Multimodality treatment of giant intracranial arteriovenous malformations. Neurosurgery 2003; 53: 1-11.
Hauck EF, Welch BG, White JA, Purdy PD, Pride LG, Samson D. Preoperative embolization of cerebral arteriovenous malformations with Onyx®. AJNR Am J Neuroradiol 2009; 30: 492-495.
Xu F, Ni W, Liao Y, Gu Y, Xu B, Leng B, et al. Onyx® embolization for the treatment of brain arteriovenous malformations. Acta Neurochir (Wien) 2011; 153: 869-978.
Natarajan SK, Ghodke B, Britz GW, Born DE, Sekhar LN. Multimodality treatment of brain arteriovenous malformations with microsurgery after embolization with onyx®; single-center experience and technical nuances. Neurosurgery 2008; 62: 1213-1225.
Chang SD, Marcellus ML, Marks MP, Levy RP, DoHM, Stemberg GK. Multimodality treatment of giant intracranial arteriovenous malformations. Neurosurgery 2003; 53: 1-11.