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2011, Number 2

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Rev Neurol Neurocir Psiquiat 2011; 44 (2)

Glucose levels in diabetic rat model in the use of olanzapine

Iniestra VE

Language: Spanish
References: 83
Page: 57-63
PDF size: 103.30 Kb.


ABSTRACT

Objective. Cuantification blood glucose and weight caused for olanzapine diabetic rats. The study was experimental, in group, prospective, incidental.
Material and methods. We made measuring of blood glucose in 20 health rats and 20 diabetic rats, selected in 4 groups with 10 rats each, group 1: health rats, group 2: health rats with olanzapine, group 3: diabetic rats, and, group 4: diabetic rats with olanzapine. The medicine was continuous 4 weeks. We recorded 5 weight and 5 glucose measures, started with baselines and weekly for 4 weeks.
Results. We recorded data set variables were analyzed using tables the values representing mean and standard deviation. With T student find significative diferences betwen experimental groups. In diabetic rats hyperglycemia occur in the fourth week and in these groups, obtained statistical differences in the weight at the end of the first week (p = 0.0001). The diabetic rats group with olanzapine was weekly die since first week and. in the fourth week only three survived whitout relation meausuring of hyperglycemia.
Conclusion. In diabetic rat with olanzapine cause hyperglycemia and it´s neccessary absolut contraindication in diabetic because they have probabylity for complications with diabetes conducing at dead.


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