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ISSN 0210-5187 (Electronic)

2016, Number 3

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Med Cutan Iber Lat Am 2016; 44 (3)

Genetics of psoriasis

Romero HM, Pereyra RJJ

Language: Spanish
References: 27
Page: 159-166
PDF size: 473.51 Kb.


ABSTRACT

Psoriasis is a chronic inflammatory disease of the skin, with a genetic component. Many studies have been carried out in order to try to figure out both the cause and the genetics behind this disease, vastly common amongst population. The next review will talk about all loci that, based on genome-wide association analysis, have been noted to confer susceptibility to suffer psoriasis. Each loci contains several genes which encode proteins that are essential to innate immunity, adaptive immunity and skin barrier function. Amongst many others, the allele HLA-C, genes which encode to IL-12 and IL-23, genes which encodes the proteins which regulate NF-κB pathways, should be hightlighted. These results open the door to future improvements in the diagnostic and treatment techniques.


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