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2016, Number 3

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Rev cubana med 2016; 55 (3)

Classical therapy versus sequential therapy in the eradication of Helicobacter pylori infection

Alonso SJ, Rojas GM, Díaz RB, Arocha SK, Manzano CT, Chao GL

Language: Spanish
References: 38
Page: 211-223
PDF size: 121.18 Kb.


ABSTRACT

Introduction: Helicobacter pylori was discovered in 1983, opening a new field in the management of diseases it causes as well as the treatment for the eradication of this bacterium.
Objective: compare the efficacy of classical treatment compared with sequential therapy in the eradication of Helicobacter pylori infection.
Method: a randomized analytical study was conducted at the Center for Medical Surgical Research from January 2013 to May 2015. A hundred sixty (160) patients were studied according to the inclusion criteria and they were divided into two groups: Group A, with 80 patients for sequential therapy and group B with 80 patients to conventional therapy.
Results: the average age of both groups was 46.0 ± 14.3 years. For patients who received conventional therapy the average age was 46.9 ± 14.6 years while the sequential therapy group was 45.2 ± 14.1 years with no significant differences in both groups (p = 0.770), nor were significant differences for sex. Erythematous antral gastritis was the most identified endoscopic diagnosis in 24.4% while moderate chronic gastritis antral was the most identified histologic diagnosis in 36.9%. 93.7% of patients who received conventional therapy eradicated Helicobacter pylori infection, representing a difference eradication regarding sequential therapy.
Conclusions: classical therapy was more effective than sequential therapy in the eradication of Helicobacter pylori.


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