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2016, Number 3

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Rev cubana med 2016; 55 (3)

Silent celiac disease in patients with type 1 diabetes mellitus

Real DRE, Ortiz GNR, Escurra ALA

Language: Spanish
References: 30
Page: 202-210
PDF size: 111.74 Kb.


ABSTRACT

Introduction: celiac disease is an autoimmune disorder induced by gluten in genetically susceptible individuals. It presents various clinical forms and it may be associated with type 1 diabetes mellitus.
Objectives: determine the frequency of celiac disease in patients with type 1 diabetes mellitus and describe its clinical features in these patients.
Methods: a prospective observational, descriptive, study was performed in 41 patients of both sexes, older than 14 years, who were affected by type 1 diabetes mellitus.
Results: high levels of transglutaminase IgA histic antibody were detected in four subjects, three of them accepted upper endoscopy; compatible histopathologic results they were found with celiac disease in all of them. None had classic symptoms of intestinal malabsorption. The mean blood glucose level of the last month was statistically higher in DM1 with celiac disease compared with DM1 without the disease (p ‹ 0.004).
Conclusion: the frequency of celiac disease in type 1 diabetes mellitus was 9.7%. The clinical form found corresponded to the silent form.


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