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ISSN 0864-4551 (Print)

2016, Number 2

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Biotecnol Apl 2016; 33 (2)

Oxidative stress in pharmacoresistant epilepsy

Lorigados L, Morales LM, Orozco-Suárez S, Gallardo JM, Díaz-Hung ML, González ME, Estupiñán B, Pavón N, Rocha L

Language: English
References: 114
Page: 2101-2107
PDF size: 296.11 Kb.


ABSTRACT

Pharmacoresistant epilepsy is a phenomenon increasingly affecting a substantial proportion of patients treated with current anti-epileptic drugs, who became refractive to therapy. Coincidently, anti-epileptic drugs have been related to oxidative stress (OS)-related processes, which could have an impact in further drug development and also disease progression. Therefore, this review is aimed to analyzing the OS processes resulting in excitotoxicity, neuroinflammation or mitochondrial dysfunction, which have been implicated in numerous neurological disorders, and particularly its role in epilepsy. Evidence from clinical data and a variety of animal models of temporal lobe epilepsy (TLE) is discussed, regarding damage to proteins, lipids, and antioxidant defenses. An emerging overall picture on the relationship of OS with cell and soluble mediators of inflammation and excitotoxicity is presented. Moreover, new therapeutic strategies are discussed, as proposed to complement current therapies or to develop new ones which could effectively interfere the chronic changes induced by recurrent seizures for a better control on the progression of the disease.


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