2016, Number 4
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Rev Mex Patol Clin Med Lab 2016; 63 (4)
Post-mortem incidental finding of uterine choriocarcinoma with multiorgan metastasis. Case report
Izaguirre GA, Rivas BA, Hasbun B, Henríquez DT
Language: Spanish
References: 20
Page: 196-201
PDF size: 475.87 Kb.
ABSTRACT
Choriocarcinoma is an epithelial malignant tumor derived from the chorionic villi, which produces β human chorionic gonadotropin (β-hCG), and is classified as a malignant trophoblastic disease along with the invasive mole and the placental site trophoblastic tumor. It is a rarely occurring neoplasm and its incidence varies widely according to the geographic region. It occurs in 1/20.000 pregnancies. We present the case of a 23-year-old patient from the rural area, Francisco Morazán, Honduras, with past obstetric history of three pregnancies, one delivery, no caesarean sections, one abortion, no stillbirths, and one offspring. She arrived to the Emergency Service of the University School Hospital in Tegucigalpa, Honduras, presenting a history of eight days of fever with shivering and no specific pattern, accompanied by chest pain, productive cough, hemoptysis, dyspnea not related to exertion, and a week of cyanosis. Her laboratory findings showed anemia, acute renal failure, and elevated tumor markers. A chest X-ray was performed, in which diffuse alveolar infiltrates were observed, as well as a thoracic computed tomography, which showed evidence of acute, subacute and chronic hemorrhage in the right lung accompanied by multiple dense lesions. The patient died eight days after her admission; therefore, an autopsy was performed, revealing the presence of a choriocarcinoma of the uterus with lung, renal and lymphatic metastases. Gestational trophoblastic neoplasia is considered the most curable of all gynecologic tumors because it is highly sensitive to chemotherapy. That is why a thorough and detailed clinical suspicion is imperative when assessing these patients.
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