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2004, Number 4

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Rev Mex Patol Clin Med Lab 2004; 51 (4)

Trypanosoma cruzi: Natural history and diagnosis of the Chagas’ disease

Carrada-Bravo T

Language: Spanish
References: 72
Page: 205-219
PDF size: 226.81 Kb.


ABSTRACT

Chagas’ disease caused by Trypanosoma cruzi is a major public health problem in the Americas, this infection is endemic in various rural areas of the Mexican Republic, where 39 triatomines species have been recorded, but only 20 have been found naturally infected by T. cruzi, principally T. barberi, T. dimidiata, Rhodnius prolixus, and T. p. pallidipennis. Also wild reservoirs have been identified such as opossums (Didelphis marsupialis), armadillos (Dasypus novemcinctus), and small rodents. Seroprevalence of T. cruzi human infection was higher in Chiapas, Oaxaca, Hidalgo, Veracruz, Yucatán, Jalisco, San Luis Potosí y Baja California. Chronic chagasic cardiomyopathy appears to be affecting large number of Mexican patients, but many acute and congenital transmission cases are underreported. Scientific research production and new publications on Chagas’ disease are rather scarce and the public health relevance of the disease remains debated, therefore much remains to be done to have a reliable and complete knowledge on vectors biology and ecology, molecular biology of the parasite, and different types and prevalence of cardiac and digestive clinical forms. This paper is a short review on the natural history and laboratory diagnosis of american trypanosomiasis, as well as the pathogenesis and pathology of the disease, epidemiology and medical treatment.


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