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2016, Number 2

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Rev Mex Angiol 2016; 44 (2)

Efecto de un polímero polisacárido con óxido de zinc en la reducción del tamaño de las úlceras venosas crónicas

Moreno-Eutimio MA, Moreno J, Cueto-García J

Language: Spanish
References: 17
Page: 67-71
PDF size: 159.48 Kb.


ABSTRACT

Background. Chronic venous ulcers (CVU) produce persistent and most annoying symptomatology in patients and unfortunately, currently there is not an effective topical product or treatment that improves healing nor the quality of life of affected patients superior to the old gold standard treatment namely the use of external venous compression and simple dressings.
Objective. To evaluate the effect in reduction of the ulcer size with the topical application of a polymer polysacharide with zinc oxide (PPOZ).
Material and methods. A controlled randomized comparative clinical study was done in patients with CVU to evaluate the effect in reduction of the area of the ulcer comparing it at the start and after eight weeks of treatment using venous compression plus the topical application of PPOZ compared to the control group treated only with venous compression and simple dressings.
Results. Topical treatment with PPOZ plus venous compression produced a smaller average area size of the ulcer compared to the control group after eight weeks of treatment (p = 0.0377) additional to a greater percentage reduction of the size of the ulcer (p = 0.0189) compared to the control group. This effect was more pronounced in the ulcers with areas › 20 cm2.
Conclusions. PPOZ is an effective therapeutic option in the treatment of CVU showing efficacy in the reduction of the ulcer size of 63.1% and healing greater than 50% of the ulcer area after eight weeks of treatment.


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