2016, Number 5
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Revista Habanera de Ciencias Médicas 2016; 15 (5)
New perspectives in the pharmacological treatment of Hepatitis C
Gómez-Aparicio S, Vicente EJ, Alegre GF
Language: Spanish
References: 22
Page: 724-743
PDF size: 166.45 Kb.
ABSTRACT
Introduction: The infection by the Hepatitis C virus (HCV) is one of the most
common causes of liver's disease worldwide. Approximately between 60-80% of
infected people, infection becomes chronic, and can lead in the long-term to the
development of other liver's diseases such as cirrhosis and the hepatocellular
carcinoma. Treatment of HCV has progressed enormously in the last decade,
concluding with the development of Direct-acting Antiviral Agents (DAA), which has
achieved cure rates over 90%.
Objective: To know the different available treatments options as well as which will be
available in a near future.
Materials and methods: Several systematic searches were made in the PubMed
database; in the articles from the "liver meeting" congress of AASLD (American
Association for the Study of Liver Diseases) in November 2014 and in the EASL
(European Association for the Study of Liver) guide.
Development: The arrivals of new drugs with new therapeutic strategies have made
this therapy more complex, and for that reason it is necessary to have knowledge of
these drugs and their possible combinations.
Conclusions: The excellent results of the therapy with AAD have made a huge
change in therapeutic recommendations, making possible shorter therapies, better
tolerated by patients and safer for health.
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