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Academia Mexicana de Neurología, A.C.

2016, Number 5

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Rev Mex Neuroci 2016; 17 (5)

The emerging role of nuclear factor erythroid 2 Nrf2 in neuroprotection mediated by astrocytes

Cuamani MG, García AON

Language: Spanish
References: 28
Page: 49-59
PDF size: 788.82 Kb.


ABSTRACT

Astrocytes are a cell type responsible for neuronal protection and homeostasis of the central nervous system, whose functions have recently reconsidered, supporting the idea that astrocytes are not only cells that provide support for other cell types but play functions such as storage and release of glycogen, control of blood flow, secretion or absorption of neural transmitters, neuroprotection against reactive oxygen species, among other functions. Neuroprotection offered by astrocytes to oxidative stress is mediated by different molecular pathways, among which the expression of Nrf2 that fosters a release of antioxidants and detoxifying agents that protect neurons against various harmful agents.


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