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Instituto Nacional de Neurología y Neurocirugía

2015, Number 1

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Arch Neurocien 2015; 20 (1)

Autism the neuroinmulogy

Rosales-Rivera LY, Velasco-Ramírez SF, Ramírez-Anguiano AC, Sánchez-Peña MJ, González-Ortíz LJ, Bitzer-Quintero OK

Language: Spanish
References: 27
Page: 54-59
PDF size: 86.60 Kb.


ABSTRACT

Autism is a group of disorders characterized by developmental deficits, severe, permanent and profound; in which directly affected the social interaction, communication, planning, imagination and emotional reciprocity. Among the mechanisms involved in its development has been proposed to be impaired and/or dysfunction of neurotransmitter systems. It is estimated that a quarter of patients with autism also suffer from seizures, previously we described the impact of the immune system during seizures; also in autism have shown alterations in both innate and adaptive immunity; there is a deregulation in some proinflammatory cytokines (IL -6, TGF-β, MIF and IL-17); involvement of different immune cells in both the nervous system and the periphery (microglia, astrocytes, NK cells and T lymphocytes). In addition the immune system, other mechanisms seem to be involved in this pathology, as some genetic factors involved in synaptic pruning during neurodevelopmental however, is still unknown how these factors for the development of autism interact.


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