2005, Number 3
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Med Int Mex 2005; 21 (3)
Transverse myelitis, a rare complication of meningitis due to Neisseria meningitidis. A report of a case and bibliographic review
Pérez CE, Vázquez ZC, Miralrio G
Language: Spanish
References: 13
Page: 240-243
PDF size: 82.90 Kb.
ABSTRACT
Neisseria meningitidis is a frequent cause of bacterial meningitis in the adult population, with a worldwide incidence of 0.9-5.1/100,000 per year. In Mexico it has been estimated an annual incidence of 0.1-0.2/100,000. Neisseria meningitidis has been classified in more than twelve serogroups and, even though the development of appropriate antimicrobials has existed through the last decades, mortality and sequelae are still high mostly because of delay in the start of treatment. The most frequent neurologic sequelae are due to an increased intracranial pressure, hydrocefalus or cranial nerve compromise. The medullar damage associated with meningitis is of ominous prognostic value; in the international literature there are just few reports of this condition, linking it to vasculitis and eventual medullary ischemic lesions, with a mortality rate of 21% and with a neurologic deficit rate in the surviving subjects up to 88%. The case of a 29 year-old woman, who suffered an acute episode of transverse myelitis due to Neisseria meningitidis meningitis and whom eventually recovered partial medullar function is presented. Also, a discussion of the latest available clinical reports of similar cases is described.
REFERENCES
Kurz S, Hübner C, Aepinus C, et al. Transcriptome-based antigen identification for Neisseria meningitidis. Vaccine 2003;21:768-75.
O‘Farell R, Thornton J, Brennan P, et al. Spinal cord infarction and tetraplegia-rare complications of meningococcal meningitis. Br J Anaesth 2000;84:514-7.
Rosenstein NE, Perkins BA, Stephens DS, et al. Meningococcal disease. N Engl J Med 2002;344:1378-88.
Perkins BA. New opportunities for prevention of meningococcal disease. JAMA 2000;283:2842-3.
Sigurdartóttir B, Björnsson O, Jonsdóttir K, et al. Acute bacterial meningitis in adults. Arch Intern Med 1997;157:425-30.
Pfister HW, Borasio GD, Dirnagl U, et al. Cerebrovascular complications of bacterial meningitis in adults. Neurology 1992;42:1497-504.
Tez S, Tunca A, Karaarslan Y, et al. Acute spinal cord dysfunction in bacterial meningitis: MRI findings. Clin Radiol 2004;59:11-14.
Moffet KS, Berkowitz FE. Quadriplegia complicating Escherichia coli meningitis in a newborn infant: case report and review of 22 cases of spinal cord dysfunction in patients with acute bacterial meningitis. Clin Infect Dis 1997;25:211-4.
Kastenbauer S, Winkler F, Fest G, et al. Acute severe spinal cord dysfunction in bacterial meningitis in adults. Arch Neurol 2001;58:806-10.
Rosenstein NE, Perkins BA, Stephens DS, et al. The changing epidemiology of meningococcal disease in the United States, 1992-1996. J Infect Dis 1999;180:1894-901.
Ishikawa N, Kikuchi H, Fujisawa I, et al. Tonsillar herniation on magnetic resonance imaging. Neurosurgery 1988;22:77-81.
Di Persio JF. Meningococcal disease: prevention and control revisited. Clin Microbiol Newsl 2001;23(20):155-9.
Nau R, Brück W. Neuronal injury in bacterial meningitis: mechanisms and implications for therapy. Trends Neurosci 2002;25(1):38-45.