Pérez-Neri I

Language: Spanish
References: 16
Page: 213-216
PDF size: 76.29 Kb.

ABSTRACT

Schizophrenia is one of the most severe psychiatric disorders. It is a chronic mental disease that may include psychotic and cognitive symptoms as well as social withdrawal. The onset of this disorder often occurs in adolescents or young adults. Several theories intend to explain the origin of schizophrenia including alterations in central nervous system development due to stress or infectious agents, as well as genetic predisposition. Whatever the case, dysfunction of several neurotransmitter systems has been associated with this disease including dopamine, glutamate and nitric oxide. Studies about those topics may help to elucidate the pathophysiology of a disease that we know better and, maybe, understand worse.

REFERENCES

1. Plomin R, DeFries J, McLearn G, McGuffin P. Behavioral Genetics. 4° Edición. Nueva York: Worth Publishers, 2001.

2. Bailer U, Leisch F, Meszaros K, Lenzinger E, Willinger U, et al. Genome scan for susceptibility loci for schizophrenia and bipolar disorder. Biol Psychiatry 2002; 52:40-52.

3. Bocchio L, Boin F, Zanardini R, Popoli M, Michelato A, et al. Association Between Promoter Polymorphic Haplotypes of Interleukin-10 gene and schizophrenia. Biol Psychiatry 2002; 51:480-4.

4. Drevets W. Schizophrenia. En Zigmond, et al. editores. Fundamental Neuroscience. San Diego: Academic Press, 1999:1554.

5. Kato C, Petronis A, Okazaki Y, Tochigi M, Umekage T, et al. Molecular Genetic Studies of Schizophrenia: Challenges and Insights. Neurosci Res. 2002; 43:295-304.

6. Drevets W. Mania. En Zigmond, et al. editores. Fundamental Neuroscience. San Diego: Academic Press, 1999:1254-5.

7. Dehaene S, Jonides J, Smith E, Spitzer M. Thinking and problem solving. En Zigmond, et al. Ed. Fundamental Neuroscience. San Diego: Academic Press, 1999.

8. Koenig J, Kirkpatrick B, Lee P. Glucocorticoid hormones and early brain development in schizophrenia. Neuropsychopharmacology 2002; 27:309-18.

9. Tsuang M, Faraone S. Schizophrenia. En Jameson J, editor. Principles of Molecular Medicine. Totowa: Humana Press, 1998.

10. Michal G. Biochemical Pathways: An atlas of biochemistry and molecular biology. Berlin: John Wiley & Sons, 1999.

11. Shibuya K, Takata N, Hojo Y, Furukawa A, Yasumatsu N, Kimoto T, Enami T, et al. Hippocampal cytochrome P450s synthesize brain neurosteroids which are paracrine neuromodulators of synaptic signal transduction. Biochim Biophys Acta 2003; 1619:301-16.

12. Bachneff S. Regional Cerebral Blood Flow in Schizophrenia and the Local Circuit Neurons Hypothesis. Schizophr Bull 1996; 22:163-82.

13. Ramírez J, Garnica R, Boll MC, Montes S, Ríos C. Low concentration of nitrite and nitrate in the cerebrospinal fluid from schizophrenic patients: a pilot study. Schizophr Res. 2003; 68:357-61.

14. McConnell H, Bianchine J. Cerebrospinal Fluid in Neurology and Psychiatry. Londres: Chapman & Hall Medical, 1994.

15. Shah A, Crespi F, Heidbreder C. Amino acid neurotransmitters: separation approaches and diagnostic value. J Chromatogr B 2002; 781:151-63.

16. McCarthy B, Gomes U, Neethling A, Shanley B, Taljaard J, Potgieter L, et al. g-aminobutyric acid concentration in cerebrospinal fluid in schizophrenia. J Neurochem 1981; 36:1406-8.