medigraphic.com
Instituto Nacional de Neurología y Neurocirugía

2015, Number 4

<< Back Next >>

Arch Neurocien 2015; 20 (4)

Contributions to the study of cortisol as a biomarker of the antisocial personality disorder

Sartori S, López M, Zabala ML, Bakker L

Language: Spanish
References: 55
Page: 251-257
PDF size: 111.99 Kb.


ABSTRACT

Aim: assess in women with diagnosis of Turner´s syndrome who presented antisocial personality disorder, morning and evening levels of cortisol and its circadian slope, in order to contribute to the discussion about the relationship between personality disorders and cortisol secretion. Material and methods: we performed an ex post facto, retrospective, descriptive and cross-sectional study with two groups. The sample was intentional and conformed by women diagnosed with Turner´s Syndrome who presented antisocial personality disorder and their respective control cases with ages between 18-40. To assess personality disorders we used the Millon Clinical Multiaxial Inventory II. Salivary free cortisol was determined, during morning and evening, to analyze the functionality of the hypothalamicpituitary- adrenal axis. Results: lower levels of morning and evening cortisol were evidenced in participants diagnosed with Turner´s Syndrome so as the existence of statistically significant differences between the results of the clinical sample and the control sample. Discussion: results allow us to observe that women with diagnosis of Turner´s Syndrome who presented antisocial personality disorders exhibit a deregulation of the hypothalamic-pituitary-adrenal axis, expressed in an alteration of the circadian rhythm of cortisol with flattening of the morning slope. Obtained data allow us to emphasize the importance of further study of the relationship between genetic and environmental factors and their subsequent expression in the psychoneuroendocrine system, in a vulnerable population as the addressed.


REFERENCES

  1. Ochsner K, Lieberman M. The emergence of social cognitive neuroscience. Am Psychol 2001; 56(9):717-34.

  2. Grande García I. Neurociencia social: el maridaje entre la psicología social y las neurociencias cognitivas. Revisión e introducción a una nueva disciplina. Anal Psicol 2009;25(1): 1-20.

  3. Alink LRA, van Ijzendoorn MH, Bakermans Kranenburg MJ, Mesman J. Cortisol and externalizing behavior in children and adolescents: mixed meta-analytic evidence for the inverse relation of basal cortisol and cortisol reactivity with externalizing behavior. Dev Psychobiol 2008; 50(5):427-50.

  4. Carré JM, Mehta PH. Importance of considering testosterone– cortisol interactions in predicting human aggression and dominance. Aggressive Behav 2011; 37(6):489-91.

  5. Feilhauer J, Cima M, Korebrits A, Nicholson NA. Salivary cortisol and psychopathy dimensions in detained antisocial adolescents. Psychoneuroendocrinology 2013;38(9):1586-95.

  6. van Goozen SH, Matthys W, Cohen Kettenis PT, Buitelaar JK, van Engeland H. Hypothalamic-pituitary-adrenal axis and autonomic nervous system activity in disruptive children and matched controls. J Am Acad Child Adolesc Psychiatry 2000; 39(11):1438-45.

  7. Gowin JL, Green CE, Alcorn JL, Swann AC. The role of cortisol and psychopathy in the cycle of violence. Psychopharmacology (Berl) 2013; 227(4):661-72.

  8. Hawes DJ, Brennan J, Dadds MR. Cortisol, callous- unemotional traits, and pathways to antisocial behavior. Curr Opin Psychiatr 2009; 22(4):357-62.

  9. O’Leary MM, Taylor J, Eckel L. Psychopathic personality traits and cortisol response to stress: the role of sex, type of stressor, and menstrual phase. Horm Behav 2010;58(2):250-6.

  10. Shirtcliff EA, Vitacco MJ, Graf AR, Gostisha AJ. Neurobiology of empathy and callousness: implications for the development of antisocial behavior. Behav Sci Law 2009; 27(2):137-71.

  11. Ranjit A, Young EA, Raghunathan TE, Kaplan GA. Modeling cortisol rhythms in population-based study. Psichoneuroendocrinology 2005;30:615-24.

  12. Rosmalen JGM, Oldehinkel AJ, Ormel J, de Winter AF, Buitelaar JK. Determinants of salivary cortisol levels in 10-12 year old children; a population-based study of individual differences. Psychoneuroendocrinology 2005; 30:483-95.

  13. Adam EK, Kumari M. Assessing salivary cortisol in largescale, epidemiological research. Psychoneuroendocrinology 2009; 34:1423-36.

  14. Kirschbaum C, Bar tussek D, Strasburger CJ. Cor tisol responses to psychosocial stress and correlations with personality traits. Pers Indiv Differ 1992;13(12):1353-7.

  15. al’Absi M, Bongard S, Lovallor WR. Adrenocorticotropin responses to interpersonal stress: effects of overt anger expression style and defensiveness. Int J Psychophysiol 2000; 37:257-65.

  16. Pérez-García AM, Sanjuán P, Bermúdez J. Control personal y situacional y reactividad cardiovascular en tareas de estrés físico. Psicothema 2000;14(3):583-90.

  17. Senior C, Loveday C. A pilot investigation into the neuroendocrine correlations of personality in the workplace. Percept Mot Skills 1998;87:794.

  18. Bossert S, Berger M, Krieg JC, Schreiber W, Junker M. Cortisol response to various stressful situations: relationship to personality variables and coping styles. Neuropsychobiology 1988;20(1):36-42.

  19. Adler LW, Wedekind D, Pilz J, Weniger G, Huether G. Endocrine correlates of personality traits: a comparison between emotionally stable and emotionally labile healthy young men. Neuropsychobiology 1997;35:205-10.

  20. Schommer NC, Kudielka BM, Hellhammer D, Kirschbaum C. No evidence for a close relationship between personality traits and circadian cor tisol rhythm or a single cortisol stress response. Psychol Rep 1999;84:840-2.

  21. Choca JP, Van Denburg E. Guía para la interpretación del MCMI. Buenos Aires: Editorial Paidós. 1998.

  22. Cima M, Smeets T, Jelicic M. Self-reported trauma, cortisol levels, and aggression in psychopathic and non-psychopathic prison inmates. Biol Psychol 2008;78(1):75-86.

  23. Fries E, Dettenborn L, Kirschbaum C. The cortisol awakening response: facts and future directions. Int J Psychophysiol 2009; 72(1):67-73.

  24. Heim C, Ehlert U, Hellhammer DH. The potential role of hypocortisolism in the pathology of stressrelated bodily disorders. Psychoneuroendocrinology 2000;25(1):1-35.

  25. McBurnett K, Lahey BB, Rathouz PJ, Loeber R. Low salivary control and persistent aggression in boys referred for disruptive behavior. Arch Gen Psychiatry 2000;57(1):38-43.

  26. Moss HB, Vanyukov MM, Yao JK, Kirillova GP. Salivary cortisol responses in the prepuberal boys: the effects of parental substance abuse and association with drug use behavior during adolescence. Biol Psychiatry 1999;45(10):1293-9.

  27. O’Leary MM, Loney BR, Eckel LA. Gender differences in the association between psychopathic personality traits and cor tisol response to induced stress. Psychoneuroendocrinology 2007;32(2):183-91.

  28. Schulz KP, Halperin JM, Newcorn JH, Sharma V. Plasma cortisol and aggression in boys with ADHD. J Am Acad Child Adolesc Psychiatry 1997;36(5):605-9.

  29. Susman EJ, Schmeelk KH, Worrall BK, Granger DA. Corticotropin releasing hormone and cortisol: longitudinal associations with depression and antisocial behavior in pregnant adolescents. J Am Acad Child Adolesc Psychiatry 1999;38(4):460-7.

  30. van Goozen S, Matthys W, Cohen Kettenis P, Gispen de Wied C, et al. Salivary cortisol and cardiovascular activity during stress in oppositional-defiant disorder boys and normal controls. Biol Psychiatry 1998;43: 531-9.

  31. Vanyukov M, Moss H, Plail J, Blackson T, Mezzich A, et al. Antisocial symptoms in preadolescent boys and in their parents: associations with cortisol. Psychiatry Res 1993;46:9-17.

  32. Welker KM, Lozoya E, Campbell JA, Neumann CS. Testosterone, cortisol and psychopathic traits in men and women. Physiol Behav 2014;129:230-6.

  33. Dolan M, Anderson IM, Deakin JF. Relationship between 5-HT function and impulsivity and aggression in male offenders with personality disorders. Br J Psychiatry 2001;178(4):352-9.

  34. Johnson MM, Caron KM, Mikolajewski AJ, Shir tcliff EA. Phychopathic traita, empathy and aggression are differentially related to cortisol awakening reponse. J Psychopathol Behav Assess 2014;36:380-8.

  35. McBurnett K, Lahey BB, Capasso L, Loeber R. Aggresive symptoms and salivary cortisol in clinic-referred boys with conduct disorder. Ann N Y Acad Sci 1996; 794(1):169-78.

  36. Murray Close D, Han G, Cicchetti D, Crick NR. Neuroendocrine regulation and physical and relational aggression: the moderating role of child maltreatment and gender. Dev Psychol 2008; 44(4):1160-76.

  37. von Polier GG. Reduce cortisol in boys with early-onset conduct disorder and callous-unemotional traits. BioMed Res Int 2013;1-9.

  38. Shoal GD, Giancola PR, Kirillova GP. Salivar y cor tisol, personality and aggressive behavior in adolescent boys: a 5- Year longitudinal study. J Am Acad Child Adolesc Psychiatry 2003;42(9):1101-7.

  39. Moss HB, Vanyukov MM, Martin CS. Salivar y cor tisol responses and the risk for substance abuse in prepuberal boys. Biol Psychiatry 1995; 38(8):547-55.

  40. Pajer K, Gardner W, Rubin RT, Perel J. Decreased cortial levels in adolescent girls with conduct disorder. Arch Gen Psychiatry 2001;58(3):297-302.

  41. Azar R, Zoccolillo M, Paquette D, Quiros E, Baltzer F, Tremblay RE. Cortisol levels and conduct disorder in adolescent mothers. J Am Acad Child Adolesc Psychiatry 2004;43(4):461-8.

  42. Sartori MS, Urquijo S, López M, Said A. Análisis de perfiles de personalidad en mujeres adultas con diagnóstico de síndrome de Turner. Interdisciplinaria En Prensa.

  43. Murphy M, Mazzocco M, Gerner G, Henry A. Mathematics learning disability in girls with Turner syndrome or fragile X syndrome. Brain Cogn 2006;61(2):195-210.

  44. López MC, Aguilar MJ. Vulnerabilidad social en el Síndrome de Turner: interacción genes- ambiente. Psicología: ciencia y profesión 2009; 29(2):318-29.

  45. Aguilar MJ, López MC, Sartori S. Autoconcepto y Síndrome de Turner: influencia de parámetros biológicos en el desarrollo psicosocial. Ac Psiquiátr Psicol Am Lat 2010;56(4):274-83.

  46. El Abd S, Turk J, Hill P. Annotation: Psychological characteristics of Turner syndrome. J Child Psychol Psychiatry 1995;36(7):1109-25.

  47. McCauley E, Sybert V. Social and behavioral development of girls and women with Turner syndrome. International Congress Series 2006;1298:93-9.

  48. Suzigan LZ, Paiva e Silva RB, Guerra Júnior G, Mariani SH, Maciel Guerra AT. Social skills in women with Turner Syndrome. Scand J Psychol 2011;52(5):440-7.

  49. Elsheikh M, Dunger DB, Conway GS, Wass JA. Turner´s syndrome in adulthood. Endocr Rev 2002;23(1):120-40.

  50. Delooz J, Van den Berghe H, Swillen A, Kleczkowska A. Turner syndrome patients as adults: a study of their cognitive profile, psychosocial functioning and psychopatho-logical findings. Genet Couns 1993;4(3):169-79.

  51. Labarta Aizpún J. Síndrome de Turner: crecimiento espontáneo y talla final. En Sociedad Española de Endocrinología Pediátrica (SEEP) (Eds.), Síndrome de Turner: 9º curso de formación de posgrado. 2004; 51-70.

  52. Asociación Americana de Psiquiatría. Guía de Consulta de los criterios diagnósticos del DSM 5. 2013. Estados Unidos: Asociación Americana de Psiquiatría.

  53. Montero I, León O. A guide for naming research studies in Psychology. Int J Clin Health Psychol 2007; 7(3):847-62.

  54. Mirasoli M, Deo SK, Lewis JC, Roda A. Bioluminescence inmunoassay for cortisol using recombinant aequorin as a label. Anal Biochem 2002; 306(2):204-11.

  55. Kesler S, Garrett A, Bender B, Yankowitz J, Zeng SM. Amygdala and hippocampal volumes in Turner syndrome: a highresolution MRI study of X-monosomy. Neuropsychologia 2004; 42:1971-8.




2020     |     www.medigraphic.com