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Colegio de Medicina Interna de México.

2016, Number 5

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Med Int Mex 2016; 32 (5)

Thyroid physiology

García-García C

Language: Spanish
References: 29
Page: 569-575
PDF size: 507.22 Kb.


ABSTRACT

Thyroid hormones have a wide range of activities in human body, even since fetal life; there are new factors that have been associated in regulation of endocrine system. There are at least four micronutrients membrane transporters in the basolateral membrane and at the colloid interface of the thyroid cell, in target cells there have been recognized membrane transporters of thyroid hormones (mct-8 and oatp-1c1), they transport t4 to the cytoplasm for its activation by deiodinase (D2) and finally binds to specific nuclear receptors (alpha-beta). All these factors take part in one of the most complex human body’s system. Also it has been proven that some enzymes depend on selenium to give protection to thyroid cell by eliminating free oxygen radicals originated by iodine peroxidation, which is an important step in thyroid hormone synthesis.


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