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2016, Number 2

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Rev cubana med 2016; 55 (2)

Clinical characterization of patients with familial hypercholesterolemia

Herrera GA, Soto MJ, Tamargo BTO, Bermúdez ML

Language: Spanish
References: 19
Page: 130-140
PDF size: 150.30 Kb.


ABSTRACT

Introduction: familial hypercholesterolemia is a genetic disorder associated with premature coronary disease due to elevated LDL cholesterol.
Objective: characterize familial hypercholesterolemia.
Methods: this is a retrospective case series study. WHO-MedPed scale was applied to 538 patients and the final sample was composed of 393 patients with score ≥ 3.
Results: there was female predominance and ageds under 60 of both sexes. Significant difference between the different strata was found by family history, but not for the risk factors. Early coronary disease and clinical manifestations as xanthomas were more frequent in the positive patients.
Conclusion: the frequency of familial hypercholesterolemia was high. Clinical manifestations are more evident in patients with positive criteria for the disorder under study. Subclinical atherosclerosis is significantly present in patients with positive criteria of familial hypercholesterolemia.


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