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Academia Mexicana de Neurología, A.C.

2005, Number 6

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Rev Mex Neuroci 2005; 6 (6)

Neurobiochemistry and pharmacology of the atypical antipsychotics

Salín-Pascual RJ

Language: Spanish
References: 61
Page: 500-507
PDF size: 71.34 Kb.


ABSTRACT

The knowledge about the existence of different neurotransmitters other than dopamine involved in schizophrenia, like serotonina and excitatory amino acids, has been relevant for the development of new molecules without extrapyramidal effects and other side effects. Such new antipsychotic drugs have been named for that reason atypical. Also, it has been very important in that field to understand that the occupancy of less than 70% of dopamine D2 receptors at the striatum, is one of the pharmacological profile of the new atypical medications, along with a higher antagonism on serotonergic 5-HT2A receptors. New drugs as olanzapine, ziprasidone, aripiprazol, risperdone and quetiapine are described in the present review. Also the description of the neurotransmitter systems as well as some aspects of atypical antipsychotics’ pharmacodinamics are mentioned, too.


REFERENCES

  1. Sawa A, Snyder SH. Schizophrenia: diverse approaches to a complex disease. Science 2002; 296(5568): 692-5.

  2. Reynolds GP. Receptor mechanisms in the treatment of schizophrenia. J Psychopharmacol 2004; 18(3): 340-5.

  3. Coffey BJ MESCRSL. Tourette’s disorder and related problems: a review and update. Harv Rev Psychiatry 1994; 2: 121-32.

  4. Mukaddes N. Quetiapine treatment of children and adolescents with Tourette’s disorder. J Child Adolesc Psychopharmacol 2003; 13(3): 295-9.

  5. Capuano B. Schizophrenia: genesis, receptorology and current therapeutics. Curr Med Chem 2004; 9: 521-48.

  6. Goodman WK. Obsessive-compulsive disorder: diagnosis and treatment. J Clin Psychiatry 2004; 60(18): 27-32.

  7. Koenigsberg HW. Risperidone in the treatment of schizotypal personality disorder. J Clin Psychiatry 2003; 64(6): 628-34.

  8. Reich JH. Effect of personality disorders on the treatment outcome of axis I conditions: an update. J Nerv Ment Dis 1993; 181(18): 475-84.

  9. Zanarini MC. Preliminary, randomized trial of fluoxetine, olanzapine, and the olanzapine-fluoxetine combination in women with borderline personality disorder. J Clin Psychiatry 2004; 65(7): 903-7.

  10. Update on dopamine receptors. Ann Clin Psychiatry 1994; 6(2): 79-90.

  11. Safferman A. Update on the clinical efficacy and side effects of clozapine. Schizophr Bull 1991; 17(2): 247-61.

  12. Ikemoto S. Ventral striatal anatomy of locomotor activity induced by cocaine, amphetamine, dopamine and D1/D2 agonists. Neuroscience 2002; 113(4): 939-55.

  13. Carpenter Jr WT. Deficit and nondeficit forms of schizophrenia: the concept. Am J Psychiatr 1988; 145: 578-83.

  14. Snyder SH. Dopamine receptors, neuroleptics, and schizophrenia. Am J Psychiatr 1981; 138: 460-4.

  15. Cannon TD. Early and late eurodevelopmental influences in the prodrome to schizophrenia: contributions of genes, environment, and their interactions. Schizophr Bull 2003; 29: 653-69.

  16. Farde L. Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects. Arch Gen Psychiatry 1992; 49(7): 538-44.

  17. Farde L, Nordstrom AL. PET analysis indicates atypical central dopamine receptor occupancy in clozapine-treated patients. Br J Psychiatry 1992; 17: 30-3.

  18. Schoemaker H, Claustre Y, Fage D, Chergui K, Curet O, Oblin A, et al. Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptorantagonist with both presynaptic and limbic selectivity. J Pharmacol Exp Ther 1997; 280: 83-97.

  19. Readler TJ, Knable MB, Jones DW, Lafargue T, Urbina RA, Egan MF, et al. In vivo olanzapine occupancy of muscarinic acetylcholine receptors in patients with schizophrenia. Neuropsychopharmacology 2000; 23(1): 58-68.

  20. Salin-Pascual RJ, Herrera-Estrella M, Galicia-Polo L, Laurrabaquio MR. Olanzapine acute administration in schizophrenic patients increases delta sleep and sleep efficiency. Biol Psychiatry 1999; 46(1): 141-3.

  21. Salin-Pascual RJ, Jiménez-Anguiano A, Granados-Fuentes D, Drucker-Colin R. Effects of biperiden on sleep at baseline and after 72 h of REM sleep deprivation in the cat. Psychopharmacology (Berl) 1992; 106(4): 540-2.

  22. Salin-Pascual RJ, Jiménez-Anguiano A. Vesamicol, an acetylcholine uptake blocker in presynaptic vesicles, suppresses rapid eye movement (REM) sleep in the rat. Psychopharmacology (Berl) 1995; 121(4): 485-7.

  23. Salin-Pascual RJ, Moro-Lopez ML, Gonzañez-Sanchez H, Blanco-Centurion C. Changes in sleep after acute and repeated administration of nicotine in the rat. Psychopharmacology (Berl) 1999; 145 (2):133-8.

  24. Domino EF. Comparison of phencyclidine and related substances with various indole, phenethylamine, and other psychotomimetics. Psychopharmacol Bull 1986; 22(3): 973-6.

  25. Meltzer HY, Li Z, Kaneda Y, Ichikawa J. Serotonin receptors: their key role in drugs to treat schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2003; 27(7): 1159-72.

  26. Puig MV, Celada P, Artigas F. Control serotoninérgico de la corteza prefrontal. Revista de Neurología 2004; 39(6): 539-47.

  27. Bortolozzi A. In vivo modulation of 5-hydroxytryptamine release in mouse prefrontal cortex by local 5-HT (2A) receptors: effect of antipsychotic drugs. Eur J Neurosci 2003; 18(5): 1235-46.

  28. Skarsfeldt T. Differential effects of repeated administration of novel antipsychotic drugs on the activity of midbrain dopamine neurons in the rat. Eur J Pharmacol 1995; 281(3): 289-94.

  29. Litman RE, Su TP, Potter WZ, Hong WW, Pickard D. Idazoxan and response to typical neuroleptics in treatment-resistent schizophrenia. Comparison with the atypical neuroleptic, clozapine. Br J Psychiatry 1996; 168(5): 571-9.

  30. Krystal JE, Abi-Dargham A, Laruelle M, Moghaddam B. Pharmacological models of psychoses. In: Charney DS, Nestler EJ, editors. New York: Oxford University Press; 2004; 287-98.

  31. Bird ED, Spokes EG, Barnes J, MacKay AV, Iversen LL, Shepherd M. Increased brain dopamine and reduced glutamic acid decarboxylase and choline acetyl transferase activity in schizophrenia and related psychoses. Lancet 1977; 2(8049):1157-8.

  32. Benes FM, Berretta S. GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder. Neuropsychopharmacology 2001; 25(1): 1-27.

  33. Benes FM, Vincent SL, Molloy R, Khan Y. Increased interaction of dopamine-immunoreactive varicosities with GABA neurons of rat medial prefrontal cortex occurs during the postweanling period. Synapse 1996; 23(4): 237-45.

  34. Impagnatiello F, Guidotti AR, Pesold C, Dwivedi Y, Caruncho H, Pisu MG et al. A decrease of reelin expression as a putative vulnerability factor in schizophrenia. PNAS 1998; 95(26): 15718-23.

  35. Tremolizzo L, Carboni G, Ruzicka WB, Mitchell CP, Sugaya I, Tueting P, et al. An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability. PNAS 2002; 99(26): 17095-100.

  36. Tandon R. Cholinergic aspects of schizophrenia. Br J Psychiatry Suppl 1999; 37: 7-11.

  37. Dalack GW, Healy DJ, Meador-Woodruff JH. Nicotine dependence in schizophrenia: clinical phenomena and laboratory findings. Am J Psychiatry 1998; 155(11): 1490-501.

  38. Benwell ME, Balfour DJ. The effects of nicotine administration on 5-HT uptake and biosynthesis in rat brain. Eur J Pharmacol 1982; 84(1-2): 71-7.

  39. Barret SP, Boileau I, Okker J, Pihl RO, Dagher A. The hedonic response to cigarette smoking is proportional to dopamine release in the human striatum as measured by positron emission tomography and craclopride. Synapse 2004; 54(2): 65-71.

  40. Croft RJ, Dimoska A, Gonsalvez CJ, Clarke AR. Suppression of P50 evoked potential component, schizotypal beliefs and smoking. Psychiatry Research 2004; 128(1): 53-62.

  41. Schoffelmeer ANM, De Vries TJ, Wardeh G, van de Ven HWM, Vanderschuren LJMJ. Psychostimulant-induced behavioral sensitization depends on nicotinic receptor activation. J Neurosci 2002; 22(8): 3269-76.

  42. Hirsch SR, Kissling W, Bauml J, Power A, ‘Connor R. A 28-week comparison of ziprasidone and haloperidol in outpatients with stable schizophrenia. J Clin Psychiatry 2002; 63(6): 516-23.

  43. Simpson GM, Glick ID, Weiden PJ, Romano SJ, Siu CO. Randomized, controlled, double-blind multicenter comparison of the efficacy and tolerability of ziprasidone and olanzapine in acutely Ill in patients with schizophrenia or schizoaffective disorder. Am J Psychiatry 2004; 161(10): 1837-47.

  44. Schmidt AW, Lebel LA, Howard J, Zorn SH. Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile. European Journal of Pharmacology 2001; 425(3): 197-201.

  45. Kingsbury SJ, Fayek M, Trufasiu D, Zada J, Simpson GM. The apparent effects of ziprasidone on plasma lipids and glucose. J Clin Psychiatry 2001; 62: 347-49.

  46. Lusskin SI, Cancro R, Chuang L, Jacobson L. Prolactin elevation with ziprasidone. Am J Psychiatry 2004; 161(10): 1925.

  47. Cheer SM, Wgstaff AJ. Quetiapine. A review of its use in the management of schizophrenia. CNS Drugs 2004; 18(3): 173-99.

  48. Richelson E, Souder T. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci 2000; 68(1): 29-39.

  49. Nemeroff CB, Kinkead B, Goldstein J. Quetiapine: preclinical studies, pharmacokynetics, drugs interactions, and dosign. J Clin Psychiatry 2003; 63(13): 5-11.

  50. Nasrallah HA, Tando R. Efficacy, safety and tolerability of quetiapina in patients with schizophrenia. J Clin Psychiatry 2002; 63(13): 13-20.

  51. DeLeon A, Patel NC, Lynn-Crismon M. Aripiprazole: a comprehensive review of its pharmacology, clinical efficacy, and tolerability. Clinical Therapeutics 2004; 26(5): 649-66.

  52. Jordan S, Koprivica V, Dunn R, Tottori K, Kikuchi T, Altar CA. In vivo effects of aripiprazole on cortical and striatal dopaminergic and serotonergic function. European Journal of Pharmacology 2004; 483(1): 45-53.

  53. Nakai S, Hirose T, Uwahodo Y, Imaoka T, Okazaki H, Miwa T, et al. Diminished catalepsy and dopamine metabolism distinguish aripiprazole from haloperidol or risperidone. European Journal of Pharmacology 2003; 472(1-2): 89-97.

  54. Leysen JE, Janssen PM, Megens AA, Schotte A. Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J Clin Psychiatry 1994; 55: 5-12.

  55. Megens AA, Awouters FH, Schotte A, Meert TF, Dugovic C, Niemegeers CJ, et al. Survey on the pharmacodynamics of the new antipsychotic risperidone. Psychopharmacology (Berl) 1994; 114(1): 9-23.

  56. Nyberg S, Farde L, Eriksson L, Halldin C, Eriksson B. 5-HT2 and D2 dopamine receptor occupancy in the living human brain. A PET study with risperidone. Psychopharmacology (Berl) 1993; 110(3): 265-72.

  57. Marder SR, Meibach RC. Risperidone in the treatment of schizophrenia. Am J Psychiatry 1994; 151(6): 825-35.

  58. Bymaster FP, Hemrick-Luecke SK, Perry KW, Fuller RW. Neurochemical evidence for antagonism by olanzapine of dopamine, serotonin, alpha 1-adrenergic and muscarinic receptors in vivo in rats. Psychopharmacology (Berl) 1996; 124(1-2): 87-94.

  59. Farde L. Brain imaging of schizophrenia -the dopamine hypothesis. Schizophr Res 1997; 28(2-3): 157-62.

  60. Farde L, Nordstrom AL, Wiesel FA, Paili S, Halldin C, Sedvall G. Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects. Arch Gen Psychiatry 1992; 49(7): 538-44.

  61. Tamminga CA, Conley RR. The application of neuroimaging techniques to drug development. J Clin Psychiatry 1997; 58(10): 3-6.




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