Butrón-López FG, Gómez-Blanco LA, Paz-García D, Ávila-Castillo A, Suárez-Serrano FJ, García-Zarco J

Language: Spanish
References: 20
Page: 144-151
PDF size: 89.89 Kb.

ABSTRACT

Objective: To assess whether ketorolac tromethamine or sodium parecoxib as adjuvants to general surgery are safe and reduce intraoperative requirements of fentanyl citrate. Material and methods: Sixty adult patients receiving general balanced anesthesia were randomized into three groups, 20 each. Group I received 50 mg IV ketorolac tromethamine, Group II, 40 mg sodium parecoxib, and the control group received placebo. All patients had clotting tests performed before and 24 hours after surgery. During surgery, bleeding was measured,and blood pressure, heart rate, and fentanyl requirements in mg/kg were recorded. In the immediate post-operative period, the time for pain to fall under 5 in the visual analogue scale (VAS) was measured. Results: No group had changes in clotting tests. Throughout surgery, bleeding remained within acceptable ranges and vital signs were normal. Both drugs reduced total fentanyl requirements, but only ketorolac tromethamine reduced them in a statistically significant way (p< 0.001). Likewise, it prolonged analgesia in the immediate post-operative period (p<0.001). Conclusions: Both ketorolac tromethamine and sodium parecoxib were demonstrated to be safe during surgery, but only ketorolac tromethamine achieved a statistically significant reduction in the intraoperative requirements of fentanyl and prolonged analgesia through the immediate post-operative period.

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