2016, Number 3
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Rev Cubana Pediatr 2016; 88 (3)
Progression of blood hypertension in the child according to treatment, and presence of left ventricular hypertrophy
González SR, Llapur MR, Fernández-Britto RJE, Bacallao GJ
Language: Spanish
References: 29
Page: 292-309
PDF size: 255.61 Kb.
ABSTRACT
Introduction: treatment of a child's blood hypertension has its own specific traits
and the progression of treatment-dependent blood pressure values have been barely
studied.
Objective: to characterize the progression of blood pressure in children with blood
hypertension according to types of treatment and presence or absence of left
ventricular hypertrophy.
Methods: cohort study conducted in 3-18 years-old children with blood hypertension,
who had been treated at Centro Habana Pediatric Hospital from 2000 to 2012. The
study variables were systolic and diastolic blood pressure, type of treatment and
presence of absence of left ventricular hypertrophy. Progression of the blood pressure
was studied by using variance analysis for repeated observations.
Results: out of 423 children under study, 43.3% were pharmacologically treated in
addition to changing their lifestyles. The most used drugs were angiotensinconverting
enzyme inhibitors and diuretics. Progression of blood pressure was
favorable in both groups, but those under drug treatment and with left ventricular
hypertrophy showed higher values.
Conclusions: the patients with drug treatment and/or left ventricular hypertrophy
have higher blood pressure figures since the onset of disease, which exceed those of
untreated patients with no hypertrophy. Children with persistent blood hypertension,
though managed, keep higher blood pressure figures.
REFERENCES
Falkner B. Hypertension in children and adolescents: epidemiology and natural history. Pediatr Nephrol. 2010;25:1219-24.
Assadi F. The Growing Epidemic of Hypertension Among Children and Adolescents: A Challenging Road Ahead. Pediatr Cardiol. 2012;33:1013-20.
Fernández-Britto JE, Barriuso A, Chiang MT, Pereira A, Xavier HT, Castillo JA, et al. La señal aterogénica temprana: estudio multinacional de 4 934 niños y jóvenes y 1 278 autopsias. Rev Cubana Invest Biomed [serie en Internet]. 2005 [citado 2 de enero de 2014];24(3). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864- 03002005000300002&lng=es&nrm=iso&tlng=es
Fernández-Britto JE, Wong R, Contreras D, Nordet P, Sternby NH. Pathomorphometrical characteristics of atherosclerosis in youth. A multinational investigation of WHO/International Society Federation Cardiology (1986-1996), using atherometric system. Nutr Metab Cardiovasc Dis. 1999 Oct;9(5):210-9.
Fernandez-Britto JE, Wong R, Contreras D, Nordet P, Sternby NH. Aterosclerosis en la juventud (i) patomorfología y morfometría según edad y sexo utilizando el sistema aterométrico. Rev Cubana Invest Biomed. 1998;17(2):128-42.
Janusz F, Maheen A. Hypertension in children: new trends and challenges. Clinical Science. 2010;119:151-61.
Xiaoli Ch, Youfa W. Tracking of Blood Pressure from Childhood to Adulthood. A Systematic Review and Meta-Regression Analysis. Circulation. 2008;117:3171-80.
Cheng S, Xanthakis V, Sullivan LM, Vasan RS. Blood pressure tracking over the adult life course: patterns and correlates in the Framingham heart study. Hypertension. 2012;60(6):1393-9.
Raj M, Braley D. Essential hypertension in adolescents and children: Recent advances in causative mechanisms Research Institute. Indian J Endocrinol Metab. 2011;15(suppl 4):S367-S373.
Lurbe E, Álvarez J, Redon J. Diagnosis and Treatment of Hypertension in Children. Curr Hypertens Rep. 2010;12:480-6.
Lurbe E, Cifkova R, Cruickshank JK, Dillon MJ, Ferreira I, Invitti C, et al. Manejo de la hipertensión arterial en niños y adolescentes: recomendaciones de la Sociedad Europea de Hipertensión. An Pediatr (Barc). 2010;73(1):e1-51-e-28.
Litwin M, Niemirska A, Śladowska-Kozlowska J, Wierzbicka A, Jamas R, Wawer ZT, et al. Regression of target organ damage in children and adolescents with primary hypertension. Pediatr Nephrol. 2010;25:2489-99.
Murphy SA. Optimal dynamic treatment regimes (with discussion). J Royal Stati Soc Series B. 2003;65:331-66.
Hernán MA, Cole SR, Margolick J, Cohen M, Robins JM. Structural accelerated failure time models for survival analysis in studies with time-varying treatments. Pharmacoepidemiol Drug Saf. 2005;14:477-91.
Hernán MA, Hernández-Díaz S, Robins JM. A structural approach to selection bias. Epidemiology. 2004;15:615-25.
Joffe M, Santana MJ, Feldman H. Partially marginal structural models for causal inference (abstract). Am J Epidemiol. 2001;153:S261.
National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescent. The Fourth Report on the diagnosis, evaluation, and treatment of High Blood Pressure in Children and Adolescents. Pediatrics. 2004;114(2 suppl):555-76.
Chandar J, Zilleruelo G. Hypertensive crisis in children. Pediatr Nephrol. 2012;27:741-51.
Berenson GS. Obesity: a critical issue in preventive cardiology the Bogalusa Heart Study. Prev Cardiol. 2005;8:234-41.
Bancalari R, Díaz C, Martínez-Aguayo A, Aglony M, Zamorano J, Cerda C, et al. Prevalencia de hipertensión arterial y su asociación con la obesidad en edad pediátrica. Rev Med Chile. 2011;139:872-9.
Minsap. Comisión Nacional Técnica asesora del Programa de Hipertensión Arterial. Guía cubanas para la prevención, diagnóstico y manejo de la hipertensión arterial. La Habana: Editorial Ciencias Médicas; 2008.
The Japanese Society of hipertensión. GUIDELINES (JSH 2009). Chapter 10. Hypertension in children. Hypertension Research. 2009;32:66-9.
Torró I, Lurbe E. Hipertension arterial en niños y adolescentes. Protocolos Diagnóstico Terapeúticos de la AEP [homepage en Internet]; Nefrología Pediátrica, 2014 [citado 2 de enero de 2014]. Disponible en: http://www.aeped.es/documentos/protocolos-nefrologia-0
Yoon EY, Davis M, Rocchini A, Kershaw D, Freed GL. Medical management of children with primary hypertension by pediatric subspecialists. Pediatr Nephrol. 2009;24:147-53.
Litwin M, Niemirska A, Sladowska J, Antoniewicz J, Daszkowska J, Wierzbicka A, et al. Left ventricular hypertrophy and arterial wall thickening in children with essential hypertension. Pediatr Nephrol. 2006;21:811-9.
McNiece KL, Gurpa-Malhotra M, Samuels J, Bell C, Garcia K, Poffenbarger T, et al. National High Blood Pressure Education Program Working Group. Left ventricular hypertrophy in hypertensive adolescents. Analysis of risk by 2004 National High Blood Pressure Education Program Working Group staging criteria. Hypertension. 2007;50:392-5.
Ramaswamy P, Lytrivi ID, Chikku P, Golden M, Kupferman JC. Regression of left ventricular hypertrophy in children with antihypertensive therapy. Pediatr Nephrol. 2007;22:141-3.
Chiolero A, Bovet P, Paradis G. Assessing secular trends in blood pressure in children and adolescents. Journal of Human Hypertension. 2009;23:426-7.
Richey PA, DiSessa TG, Somes GW, Alpert BS, Jones DP. Left Ventricular Geometry in Children and Adolescents with Primary Hypertension. Am J Hypertens. 2010;23:24-9.