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2016, Number 1

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Rev Cubana Hematol Inmunol Hemoter 2016; 32 (1)

Iron metabolism regulation: two systems, one goal

Forrellat BM

Language: Spanish
References: 15
Page: 4-14
PDF size: 524.61 Kb.


ABSTRACT

Human existence is indissolubly linked to iron, which is part of a wide variety of key enzymes such as catalase, aconitases, ribonucleotide reductase, peroxidases and cytochromes, exploiting the flexibility of its redox chemistry to run a large number of reactions essential for life. Human body has evolved to keep iron in different forms, including recycling after rupture of erythrocytes and the retention without excretion mechanism. Iron metabolism is balanced by two regulatory systems: one based on systemic hormone hepcidin protein export and ferroportin, and the other, which controls cell metabolism through the iron regulatory protein (IRP) binding to the mRNAs regulated iron regulatory elements (IRE). These systems work in a coordinated manner avoiding both deficiency and excess.


REFERENCES

  1. Abbaspour N, Hurrell R, Kelishadi R. Review on iron and its importance for human health. J Res Med Sci. 2014 Feb;19(2):164–74.

  2. Finberg KE. Unraveling mechanisms regulating systematic iron homeostasis. Hematology Am Soc Hematol Educ Program. 2011;2011: 532–537. doi:10.1182/asheducation-2011.1.532.

  3. Fleming MD. Disorders of Iron and Copper Metabolism, the Sideroblastic Anemias, and Lead Toxicity. In: Orkin SH, Fisher DE, Ginsburg D, Look T, Lux SE, Nathan DG. Nathan and Oski´s Hematology and Oncology of Infancy and Childhood. 8th ed. Philadelphia: Elsevier Saunders; 2015.

  4. Hentze MW, Muckenthaler MU, Galy B, Camaschella C. Two to Tango: Regulation of Mammalian Iron Metabolism. Cell. 2010 Jul;142(1):24-38.

  5. Camaschela C. Iron Deficiency Anemia. New Engl J Med. 2015 May;372(19):1832-43.

  6. Fleming RE, Pomka R. Iron overload in human disease. New Engl J Med. 2012;366(4):348-59.

  7. Donker AE, Raymakers RAP, Vlasveld LT, van Barneveld T, Terink, R, Dors N, et al. Practice guidelines for the diagnosis and management of microcytic anemias due to genetic disorders of iron metabolism or heme synthesis. Blood. 2014;123(25):3873- 86. DOI 10.1182/blood-2014-01-548776.

  8. Wang J, Pantopoulos K. Regulation of cellular iron metabolism. Biochem J. 2011;434:365–81.

  9. Theil EC, Chen H, Miranda C, Janser H, Elsenhans B, Núñez MT, et al. Absorption of iron from ferritin is independent of heme iron and ferrous salts in women and rat intestinal segments. J Nutr. 2012;142:478–83.

  10. Meynard D, Babitt JL, Lin HY. The liver: conductor of systemic iron balance. Blood. 2014 Ene; 123(2): 168-75. DOI 10.1182/blood-2013-06-427757.

  11. Camaschella C. Iron and hepcidin: a story of recycling and balance. Hematology Am Soc Hematol Educ Program. 2013;2013:1-8. doi: 10.1182/asheducation- 2013.1.1.

  12. Ganz T, Nemeth E. Iron Metabolism: Interactions with Normal and Disordered Erythropoiesis. Cold Spring Harb Perspect Med. 2012;2:a011668.

  13. Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet. 2014 July;46(7):678–684. doi:10.1038/ng.2996.

  14. Hurrell R, Egli I. Iron bioavailability and dietary reference values. Am J Clin Nutr. 2010;91:1461–7S.

  15. Mastrogiannaki M, Matak P, Peyssonnaux C. The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions. Blood. 2013 Aug;122(6):885-91.doi:10.1182/blood-2012-11-427765.




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