Romo JE, Loera OF, Adame DR, Estrada A, Díaz JD, Reier P

Language: Spanish
References: 24
Page: 429-434
PDF size: 371.36 Kb.

ABSTRACT

The olfactory bulb is a nervous system structure where the injured axons are able to regenerate themselves, and this ability has fostered trials in which unsheathing glia encircling in adult rats is purified to transplant it and to utilize its regenerating potential in spinal cords injured; reports show that injured medullary axons can long-distance regenerate in transacted spinal cords. Thus, the olfactory bulb cell transplant has arisen like a promising therapy for the traumatic spinal cord repair and other neurodegenerative illnesses (multiple sclerosis). The biomedical basic science advances focused to this subject (spinal cord injury and regeneration) has led to a variety of individualistic experimental therapeutics that promotes efficient results in experimental animals. Several proposals have been added to the conventional protocol established by Almudena Ramón Cueto M. D., in the 90’s, as, for example, the Schwann’s cells addition as precursor factors of remielinization, nervous and non-nervous tissue transplants with a high potential capacity to rebuild synaptic circuits, NT-3 and GDNF application to increase the neuron number without increasing their differentiation and some others that propose the use of methylprednisolone and interleukin-10 as anti-inflammatory capable of reducing the tissue loss of CNS and so offering an additional protection against the injury mechanism.

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