Padilla DB, Dorta CAJ, Noris GE

Language: Spanish
References: 16
Page: 310-314
PDF size: 250.31 Kb.

ABSTRACT

Objective: To review the role of the complement system in infectious, autoimmune and degenerative diseases. Development: The components of Complement System could arrive to the central nervous system by diffusion throughout the blood-brain barrier or it may be synthesized in the proper central nervous system. It can be activated in the presence of antibodies such in infectious disorders or by links of C1q with b amiloid protein, Amiloid P protein or C-reactive protein in Alzheimer Disease. Intrathecal synthesis of C3c and C4 can be observed in infectious diseases. The complement system can be involved in the clearing of myelin rest as well as in axon remyelinization and in neurodegenerative disease like Parkinson and Alzheimer, complement factors play a roll in the physiopathology of such disorders because its activation was reported by determined proteins. In autoimmune diseases like miastenia gravis, the activation of the complement system could produce a deterioration of the patient. Conclusion: Complement system play an important role in the infectious, autoimmune and degenerative disorders in its physiopathology. The knowledge of this process can be important for therapeutics purposes.

REFERENCES

1. Carroll MC. The role of complement and complement receptors in induction and regulation of immunity. Annu Rev Immunol 1998; 16: 545-68.

2. Song WC, Sarrias MR, Lambris JD. Complement and innate immunity. Immunopharmacology 2000; 49: 187-98.

3. Sunyer JO, Lambris JD. Evolution and diversity of the complement system of poikilothermic vertebrates. Immunol Rev 1998; 166: 39-57.

4. Lambris JD. The third component of complement: chemistry and biology. Curr Topics Microb Immunol 1990; 153:45-72.

5. Perkins SJ, Sim RB. Molecular modeling of human complement component C3 and its fragments by solution scattering. Eur J Biochem 1986; 157: 155-68.

6. Dimitrios M, Dimitrios M, Stuart NI, Holland MC, Lambris JD. Complement. Structure, functions, evolution, and viral molecular mimicry. Inmunologic Research 2003; 27: 367-85.

7. Yasojima K, McGeer PL. Up-regulated production and activation of the complement system in Alzheimer’s disease brain. Am J Pathol 1999; 154: 927-36.

8. Trbojevic-Cepe M, Brinar V, Pauro M, Vogrinc Z, Stambuk N. Cerebrospinal fluid complement activation in neurological diseases. J Neurol Sci 1998; 54: 173-81.

9. Gasque P, Dean YD, McGreal EP, VanBeek J, Morgan BP. Complement components of the innate immune system in health and disease in the CNS. Immunopharmacology 2000; 49: 171-86.

10. Barnum SR. The complement system in demyelinating disease. Mol Chem Neuropathol1997; 31: 289-300.

11. Tatomirovic Z, Bokun R, Bokonjic D. Intrathecal synthesis of complement components C3c and C4 in the central nervous system infections with signs of the acute serous meningitis síndrome. Vojnosanit Pregl 2000; 59: 265-70.

12. Boos LA, Szalai AJ, Barnum S. Murine Complement C4 is not required for experimental autoinmune encefalomyelitis. J Inmunol 2004; 49: 158-60.

13. Muñoz DG, Erkinjuntti T, Gaytán García S, Hachinski V. Serum protein leakage in Alzheimer’s disease revisited. Ann NY Acad Sci 1997; 826: 173-89.

14. Veerhuis R, Janssen I, De Groot CJ, Van Muiswinkel FL, Hack CE, Eikelenboom P. Cytokines associated with amyloid plaques in Alzheimer’s disease brain stimulate human glial and neuronal cell cultures to secrete early complement proteins, but not C1-inhibitor. Exp Neurol 1999; 160: 289-99.

15. Rozemuller AJ, Eikelenboom P, Theeuwes JW, Jansen Steur EN, de Vos RA. Activated microglial cells and complement factors are unrelated to cortical Lewy bodies. Acta Neuropathol (Berl) 2000; 100: 701-8.

16. Thorlacius S, Mollnes TE, Garred P, Aarli JA, Matre R, Tonder O, et al. Plasma exchange in myasthenia gravis: changes in serum complement and immunoglobulins. Acta Neurol Scand 1988; 78: 221-7.