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2004, Number 3

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Rev Mex Anest 2004; 27 (3)

Comparison of oxcarbazepine and gabapentin at standard dose in treatment of pain for postherpetic neuropathy

Venancio-Ramírez L, Hernández-Santos JR, Tenopala-Villegas S, Torres-Huerta JC, Rivera-León G, Canseco-Aguilar C

Language: Spanish
References: 17
Page: 129-133
PDF size: 100.28 Kb.


ABSTRACT

Objective: To assess postherpetic pain control with oxcarbazepine vs gabapentin.Material and methods: Thirty patients over 60 years old, with postherpetic neurophaty and poor pain control, were randomized into two groups, 15 each. Group A received oxcarbazepine and Group B received gabapentin, both at 600 mg/day, as well as supplementary medication with tramadol drops, 1 mg/kg body weight, and amitriptyline, 25 mg/day. Analgesia was assessed using a visual analogue scale (VAS), allodynia and hyperalgesia, as well as side effects at the treatment start and during the four following weeks. Results: VAS: Group A showed a gradual decrease, from 8 to 2.8 by the fourth week of treatment (p < 0.05).Group B showed a decrease from 8.5 to 1 by the fourth week (p < 0.05). Mechanical allodynia and hyperalgesia had decreased by the end of the treatment (p < 0.05), showing statistically significant differences in both groups. Side effects were somnolence dizziness, headache, nausea and fatigue; the three latter showed no statistically significant differences among groups.Conclusions: Both drugs showed a similar analgesic effectiveness and a gradual decrease in allodynia and hyperalgesia, but oxcarbazepine showed a higher incidence of side effects.


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