Chablé-Montero F, Cano-García F, Córdova-Ramón JC, Albores-Saavedra J

Language: Spanish
References: 24
Page: 82-86
PDF size: 200.79 Kb.

ABSTRACT

Renal angiomyolipoma (RAML) is a rare tumor accounting for 2-3% of all kidney tumors, and it is composed of abnormal blood vessels, smooth muscle and adipose tissue. The aim was to review the demographic and clinicopathological data of AMLRs studied at Medica Sur Hospital for compare it with those reported by other series. Among 310 nephrectomies, we identified 10 cases of RAML, which represented 3.2% of the nephrectomies and 4.6% of all renal tumors (276 tumors). Women predominated (7 cases) over men (3 cases). The average age of patients was 53.8 years (range 41-66 years), however, when the age was adjusted to sex, women developed these tumors 10 years earlier than men (50.8 vs. 60.6 years). The most frequently affected kidney was the left (6 cases). Four patients underwent total nephrectomy because they presented with hypovolemic shock due to spontaneous rupture of the tumor. None of the cases were associated with tuberous sclerosis or renal cell carcinoma. None of the cases recurred locally or caused the dead of the patients at 15 months of follow-up.

REFERENCES

1. Farrow GM, Harrison EG Jr., Utz DC, Jones DR. Renal angiomyolipoma. A clinicopathologic study of 32 cases. Cancer 1968; 22(3): 564-70.

2. López Ramírez JM, Ramos-Arredondo PE, Hernández-Ordóñez OF. Experiencia de angiomiolipoma renal en el Hospital de Especialidades Centro Médico “La Raza”. Col Mex Urol 2002; 17(1): 39-44.

3. Martin HL, Lee E, Albores-Saavedra J. Secondary parathyroid hyperplasia in tuberous sclerosis: report of a case with large eosinophilic ganglion-like cells similar to those of subependymal giant cell astrocytoma, tubers, and atypical angiomyolipoma. Am J Surg Pathol 2002; 26(2): 260-5.

4. Morgan GS, Straumford J, Hall EJ. Angiomiolipoma of the kidney. J Urol 1951; 65: 625.

5. Inglis K. The nature and origin of smooth muscle-like neoplastic tissue in renal tumors of the tuberous sclerosis complex. Cancer 1960; 13: 602-11.

6. Haas NB, Nathanson KL. Hereditary kidney cancer syndromes. Adv Chronic Kidney Dis 2014; 21(1): 81-90.

7. Von-Ranke FM, Zanetti G, Silva JL, Neto CA, Godoy MC, Souza CA, Mançano AD, et al. Tuberous Sclerosis Complex: State-ofthe- Art Review with a Focus on Pulmonary Involvement. Lung 2015; 193(5): 619-27.

8. Stone NN, Atlas I, Kim US, Kwan D, Leventhal I, Waxman JS. Renal angiomyolipoma associated with neurofibromatosis and primary carcinoid of mesentery. Urology 1993; 41(1): 66-71.

9. Aydin H, Magi-Galluzzi C, Lane BR, Sercia L, Lopez JI, Rini BI, Zhou M. Renal angiomyolipoma: clinicopathologic study of 194 cases with emphasis on the epithelioid histology and tuberous sclerosis association. Am J Surg Pathol 2009; 33(2): 289-97.

10. Wegryn J, Resnick IM. Angiomyolipoma diagnosis and conservative management. Contemporary Urology 1998: 56-64.

11. Chesa-Ponce N, Artiles-Hernández JL, Ponce-Socorro JM, del- Rosario-Medina J, Castro-López-Torrella V, Betancort-de-León R. Wunderlich’s syndrome as the first manifestation of a renal angiomyolipoma. Arch Esp Urol 1995; 48(3): 305-8.

12. Delgado R, de Leon Bojorge B, Albores-Saavedra J. Atypical angiomyolipoma of the kidney: a distinct morphologic variant that is easily confused with a variety of malignant neoplasms. Cancer 1998; 83(8): 1581-92.

13. Ashfaq R, Weinberg AG, Albores-Saavedra J. Renal angiomyolipomas and HMB-45 reactivity. Cancer 1993; 71(10): 3091-7.

14. Thway K, Fisher C. PEComa: morphology and genetics of a complex tumor family. Ann Diagn Pathol 2015; 19(5): 359-68.

15. Myoen S, Mitsuzuka K, Saito H, Ota H, Takase K, Arai Y. Spontaneous rupture of a renal angiomyolipoma at 25 weeks of pregnancy treated with transarterial embolization: A case report and review of the literature. Int J Urol 2015; 22(7): 710-2.

16. Iruloh C, Keriakos R, Smith DJ, Cleveland T. Renal angiomyolipoma and lymphangioleiomyomatosis in pregnancy. J Obstet Gynaecol 2013; 33(6): 542-6.

17. Mouded IM, Tolia BM, Bernie JE, Newman HR. Symptomatic renal angiomyolipoma, report of 8 cases, 2 with spontaneous rupture. J Urol 1978; 119(5): 684-8.

18. Huang JK, Ho DM, Wang JH, Chou YH, Chen MT, Chang SS. Coincidental angiomyolipoma and renal cell carcinoma: report of 1 case and review of literature. J Urol 1988; 140(6): 1516-8.

19. Khaitan A, Hemal AK, Seth A, Gupta NP, Gulati MS, Dogra PN. Management of renal angiomyolipoma in complex clinical situations. Urol Int 2001; 67(1): 28-33.

20. Zagoria RJ, Dyer RB, Assimos DG, Scharling ES, Quinn SF. Spontaneous perinephric hemorrhage: imaging and management. J Urol 1991; 145(3): 468-71.

21. Budde K, Gaedeke J. Tuberous sclerosis complex-associated angiomyolipomas: focus on mTOR inhibition. Am J Kidney Dis 2012; 59(2): 276-83.

22. Citak EC, Yilmaz EB, Yaman E, Kaya S, Taskinlar H, Arpaci RB, Apaydin D. Malignant epitheloid angiomyolipoma of the kidney in a child treated with sunitinib, everolimus and axitinib. Can Urol Assoc J 2015; 9(7-8): E542-E545.

23. Nonomura A, Enomoto Y, Takeda M, Takano M, Morita K, Kasai T. Angiomyolipoma of the liver: a reappraisal of morphological features and delineation of new characteristic histological features from the clinicopathological findings of 55 tumours in 47 patients. Histopathology 2012; 61(5): 863-80.

24. Tallarigo C, Baldassarre R, Bianchi G, Comunale L, Olivo G, Pea M, Bonetti F, et al. Diagnostic and therapeutic problems in multicentric renal angiomyolipoma. J Urol 1992; 148(6): 1880-4.