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2015, Number 3

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Med Sur 2015; 22 (3)

Correlation of neutrophil gelatinase-associated lipocalin (NGAL) value and acute kidney injury staging

Escamilla-Illescas D, Cárdenas-Membrila G, Cárdenas-Ortega A, Briones-Torres Carlo-Andrés

Language: Spanish
References: 14
Page: 127-131
PDF size: 134.28 Kb.


ABSTRACT

Introduction. Neutrophilgelatinase associated lipocalin (NGAL) has beenrelated to the early diagnosis of acute kidney injury (AKI). Objective. To determine ifthere’s a lineal increase of NGAL value related to AKI stage classification. Material and methods. An observational and prospective study was conducted includingpatient swith AKI diagnosis admitted at intensive careunit of Medica Sur Hospital. Serum NGAL value swere me asured at the diagnosis of AKI and at 24 h later. In some cases it was possible to obtain this value at 24 h before the diagnosis. It was evaluated the possible correlation between NGAL values and AKI stage. For the statistical analys is we use t test with p ≥ 0.05. Results. A total of 51 patients were included. Twenty-five percent presented AKI at the beginning, while 11.7% developed it during the stay and 62.7% didn’t presented. The mean value of NGAL the day before AKI diagnosis was 347.9 ± 497 (p=0.01) with a mean increase value of 749.6 ± 1,484 (p=0.03) on the day of the diagnosis; for the next day the NGAL value was 503.1 ± 754 (p=0.009). According to the KDIGO classification, the NGAL values did not significantly correlate with stages of AKI. Conclusion. We corroborated the NGAL value elevation before the clinical AKI diagnosis. However, we did not findany correlation between NGAL value and AKI severity.


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