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ISSN 1727-897X (Electronic)

2016, Number 3

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Medisur 2016; 14 (3)

Immune response to Ebola virus infection

Alonso RA, Pérez CM, Pardo MD, Piloto OY, Ojeda MB, Casenave-Cambet RR

Language: Spanish
References: 30
Page: 313-319
PDF size: 177.77 Kb.


ABSTRACT

Ebola virus belongs to the family Filoviridae and causes a highly lethal hemorrhagic fever. Affected patients show an impaired immune response as a result of the evasion mechanisms employed by the virus. Cathepsin is an enzyme present in the granules of phagocytes which cleaves viral surface glycoproteins, allowing virus entry into the host cell. In addition, this virus is resistant to the antiviral effects of type I interferon, promotes the synthesis of proinflammatory cytokines and induces apoptosis of monocytes and lymphocytes. It also induces an incomplete activation of dendritic cells, thus avoiding the presentation of viral antigens. Although specific antibodies are produced after the first week, their neutralizing capacity is doubtful. The virus evades the immune response and replicates uncontrollably in the host. This paper aims to summarize the main characteristics of the immune response to Ebola virus infection.


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