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2016, Number 2

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Rev Mex Patol Clin Med Lab 2016; 63 (2)

Helicobacter pylori: pathogenicity mechanisms

Cervantes-García E

Language: English
References: 63
Page: 100-109
PDF size: 375.97 Kb.


ABSTRACT

Helicobacter pylori is a Gram-negative microaerophilic bacteria that inhabits the stomach of humans. H. pylori is the causal agent of gastritis, peptic ulcer and gastric cancer. Eradication of Helicobacter pylori infection in Mexico is a priority due to the elevated seroprevalence; however, there is very little information about antibiotic resistance rates in H. pylori isolates in our country. The increased prevalence of antibiotic resistance has become a worldwide problem and makes the treatment of H. pylori infection difficult. Infection due to H. pylori affects more than 50% of the world population and is the leading cause of development of affections like gastric and duodenal ulcers, and gastric cancer. It is known that most infected people do not develop any of these diseases because the pathogenesis induced by this microorganism depends on different factors, including the host features, the environment where it is developed and the infectious strain. This work reviews and updates our knowledge on the pathogenesis of the infection due to H. pylori and the main virulence factors leading to the development of severe affections, and thus, contributes to a better treatment of this infection in our population, which presents a high prevalence of H. pylori.


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