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Academia Mexicana de Neurología, A.C.

2016, Number 2

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Rev Mex Neuroci 2016; 17 (2)

Distribution of neuropeptides in human brain

Duque-Díaz E, Rita-Gáfaro C, Bermúdez M

Language: Spanish
References: 50
Page: 71-82
PDF size: 253.20 Kb.


ABSTRACT

The human brain has been used in laboratory as an experimental model in order to answer several scientific questions related to neuroanatomy, neurophysiology, neuropharmacology, neurology and behavior. The brain is the organ in which functions take place for the regulation of reflexes and unconscious mechanisms (transmission of pain, cardiovascular, respiratory, etc.). These mechanisms are mediated by chemicals such as neuropeptides, which are short chains of amino acids that have been shown are widely distributed in the central and peripheral nervous system and also to exert physiological actions acting as neurotransmitters, neuromodulators (paracrine action and autocrine) and neurohormones. In the last thirty years, knowledge has increased on the distribution and function of neuropeptides in the central nervous system of mammals (rats, cats, dogs, alpacas, primates and humans). Thus, the aim of this paper is to describe the most relevant information available about neuropeptides in the human brain. To do so will raise issues such as:
1. 1) The distribution of neuropeptides.
2. 2) The anatomical relationship among the different neuropeptides.
3. 3) The physiological functions of the neuropeptides.
4. 4) The coexistence of neuropeptides.
5. 5) The future research about the neuropeptides.


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