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Instituto Nacional de Salud Pública

2005, Number 3

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salud publica mex 2005; 47 (3)

Clinical profile of dengue hemorrhagic fever cases in Mexico

Navarrete-Espinosa J, Gómez-Dantés H, Celis-Quintal JG, Vázquez-Martínez JL

Language: English
References: 65
Page: 193-200
PDF size: 132.77 Kb.


ABSTRACT

Objective. Dengue hemorrhagic fever is a public health problem in Mexico since 1994. With four serotypes circulating the risk of epidemic dengue hemorrhagic fever is increasing. Material and Methods. We describe the clinical features of confirmed cases in the social security health system (IMSS) from 1995 to 2003. Clinical picture and epidemiological features were compared and a multivariate model was fitted to evaluate associations. Results. Cases were divided into two groups: 438 patients with dengue fever, including 109 cases with hemorrhagic manifestations without thrombocytopenia, and 977 cases with dengue hemorrhagic fever, including 79 deaths. The main risk factors associated with mortality were hematemesis (RR 2.6; CI 95% 1.4-4.6) and melena (RR 2.2; CI 95% 1.2-3.7). Conclusions. Our results characterize the clinical profile of dengue hemorrhagic fever cases in Mexico and identify prognostic factors to alert clinician for the prevention of a fatal evolution.


REFERENCES

  1. Jacobs M. Dengue: Emergence as a global public health problem and prospects for control. Trans Royal Soc Trop Med Hyg 2000;94:7-8.

  2. World Health Organization. Report on global surveillance of epidemic-prone infectious diseases. WHO/CDS/CSR/ISR/2000.1

  3. Guzmán MG, Kourí G. Dengue and dengue hemorrhagic fever in the Americas: lessons and challenges. J Clin Virol 2003;27(1):1-13.

  4. Boletines Epidemiológicos 1979-2002. Coordinación de Salud Pública. Instituto Mexicano del Seguro Social.

  5. Narro-Robles J, Gómez-Dantés H. El dengue en México: un problema prioritario de salud pública. Salud Publica Mex 1995;37 supl:S12-S20.

  6. Guzmán MG, Kourí G. Dengue: An update. Lancet Infect Dis 2002;2(1):33-42.

  7. Gubler DJ. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev 1998;11(3):480-496.

  8. World Health Organization. Dengue haemorrhagic fever: Diagnosis, treatment, prevention and control. Geneva: WHO; 1997.

  9. Cuzzubbo AJ, Vaughn DW, Nisalak A, Solomon T, Kalayanarooj S, Aaskov J et al. Comparison of PanBio dengue duo enzyme-linked immunosorbent assay (ELISA) and MRL dengue fever virus immunoglobulin M capture ELISA for diagnosis of denguevirus infections in

  10. Southeast Asia. Clin Diagn Lab Immunol 1999;6(5):705-712.

  11. Porter KR, Widjaja S, Lohita HD, Hadiwijaya SH, Maroef CN, Suharyono W et al. Evaluation of a commercially available immunoglobulin M capture enzyme-linked immunosorbent assay kit for diagnosing acute dengue infections. Clin Diagn Lab Immunol 1999;6(5):741-744.

  12. Ramos C, García H, Villaseca JM. Fiebre hemorrágica y síndrome de choque por dengue. Salud Publica Mex 1993;35(1):39-55.

  13. Bustos J, Hamdan A, Loroño MA. Serologically proven acute rubella infection in patients with clinical diagnosis of dengue. Epidemiol Infect 1990;104(2):297-302.

  14. Zavala VJ, Vado SI, Rodríguez FM, Rodríguez AE, Barrera PM, Guzmán ME. Leptospirosis anictérica en un brote epidémico de dengue en la Península de Yucatán. Rev Biomed 1998;9(2):78-83.

  15. Zavala VJ, Yu XJ, Walker DH. Unrecognized spotted fever group rickettsiosis masquerading as dengue fever in Mexico. Am J Trop Med Hyg 1996;55(2):157-159.

  16. Qiu FX, Chen QQ, Ho QY, Chen WZ, Zhao ZG, Zhao BW. The first epidemic of dengue hemorrhagic fever in the people’s Republic of China. Am J Trop Med Hyg 1991;44(4):364-370.

  17. Cobra C, Rigau-Pérez JG, Kuno G, Vorndam V. Symptoms of dengue fever in relation to host immunologic response and virus serotype, Puerto Rico, 1990-1991. Am J Epidemiol 1995;142(11):1204-1211.

  18. Halstead SB. Dengue and hemorrhagic fevers of southeast Asia. The Yale Journal of Biology and Medicine 1965;37(6):434-454.

  19. Hayes CG, Manaloto CR, González A, Ranoa CP. Dengue infections in the Philippines: clinical and virological findings in 517 hospitalized patients. Am J Trop Med Hyg 1988;39(1):110-116.

  20. Qiu FX, Gubler DJ, Liu J Ch, Chen QQ. Dengue in China: A clinical review. Bull World Health Organ 1993;71(3/4):349-359.

  21. Rigau-Pérez JG. Clinical manifestations of dengue hemorrhagic fever in Puerto Rico, 1990-1991. Pan Am J Public Health 1997;1(5):381-388.

  22. George R, Lum L. Clinical spectrum of dengue infection. En: Gubler DJ, Kuno G. Dengue and dengue hemorrhagic fever. Wallingford, UK: CAB International 1997:89-113.

  23. Nelson E, Chulajata R. Danger signs in Thai hemorrhagic fever (dengue). Tropical Pediatrics 1965;67(3):463-470.

  24. Nelson ER. Hemorrhagic fever in children in Thailand. Report of 69 cases. Tropical Pediatrics 1960;56(1):101-108.

  25. Kabra SK, Verma IC, Arora NK, Jain Y, Kaira V. Dengue hemorrhagic fever in children in Delhi. Bull World Health Organ 1992;70(1):105-108.

  26. Guzmán MG, Kourí GP, Martínez E, Bravo J, Rivero R, Soler M. Clinical and serologic study of Cuban children with dengue hemorrhagic/dengue shock syndrome (DHF/DSS). Bull Pan Am Health Organ 1987;21(3):270-279.

  27. Díaz A, Kourí GP, Guzmán MG, Lobaina L, Bravo J, Ruiz A et al. Cuadro clínico de la fiebre hemorrágica del dengue/ síndrome de choque del dengue en el adulto. Bol Of Sanit Panam 1988;104(6):560-571.

  28. Kourí GP, Guzmán MG, Bravo JR, Triana C. Dengue hemorrhagic fever/ dengue shock syndrome: lessons from the Cuban epidemic, 1981. Bull World Health Organ 1989;67(4):375-380.

  29. Valdés L, Guzmán MG, Kourí GP, Delgado J, Carbonell I, Cabrera MV et al. La epidemiología del dengue y el dengue hemorrágico en Santiago de Cuba, 1997. Rev Panam Salud Publica 1999;6(1):16-24.

  30. Guzmán MG, Vázquez S, Martínez E, Alvarez M, Rodríguez R, Kourí G et al. Dengue en Nicaragua, 1994: reintroducción del serotipo 3 en las Américas. Bol Oficina Sanit Panam 1996;121(2):103-110.

  31. Rigau-Pérez JG, Bonilla GL. An evaluation of modified case definitions for the detection of dengue hemorrhagic fever. Puerto Rico Association of Epidemiologists. P R Health Sci J 1999;18(4):347-352.

  32. Halstead S. Is there an inapparent dengue explosion? Lancet 1999;353:1100.

  33. Reynes JM, Laurent A, Deubel V, Telliam E, Moreau JP. The first epidemic of dengue hemorrhagic fever in French Guiana. Am J Trop Med Hyg 1994;51(5):545-553.

  34. Jacobs M. Dengue: Emergence as a global public health problem and prospects for control. Trans Royal Soc Trop Med Hyg 2000;94:7-8.

  35. World Health Organization. Report on global surveillance of epidemic-prone infectious diseases. WHO/CDS/CSR/ISR/2000.1

  36. Guzmán MG, Kourí G. Dengue and dengue hemorrhagic fever in the Americas: lessons and challenges. J Clin Virol 2003;27(1):1-13.

  37. Boletines Epidemiológicos 1979-2002. Coordinación de Salud Pública. Instituto Mexicano del Seguro Social.

  38. Narro-Robles J, Gómez-Dantés H. El dengue en México: un problema prioritario de salud pública. Salud Publica Mex 1995;37 supl:S12-S20.

  39. Guzmán MG, Kourí G. Dengue: An update. Lancet Infect Dis 2002;2(1):33-42.

  40. Gubler DJ. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev 1998;11(3):480-496.

  41. World Health Organization. Dengue haemorrhagic fever: Diagnosis, treatment, prevention and control. Geneva: WHO; 1997.

  42. Cuzzubbo AJ, Vaughn DW, Nisalak A, Solomon T, Kalayanarooj S, Aaskov J et al. Comparison of PanBio dengue duo enzyme-linked immunosorbent assay (ELISA) and MRL dengue fever virus immunoglobulin M capture ELISA for diagnosis of denguevirus infections in Southeast Asia. Clin Diagn Lab Immunol 1999;6(5):705-712.

  43. Porter KR, Widjaja S, Lohita HD, Hadiwijaya SH, Maroef CN, Suharyono W et al. Evaluation of a commercially available immunoglobulin M capture enzyme-linked immunosorbent assay kit for diagnosing acute dengue infections. Clin Diagn Lab Immunol 1999;6(5):741-744.

  44. Ramos C, García H, Villaseca JM. Fiebre hemorrágica y síndrome de choque por dengue. Salud Publica Mex 1993;35(1):39-55.

  45. Bustos J, Hamdan A, Loroño MA. Serologically proven acute rubella infection in patients with clinical diagnosis of dengue. Epidemiol Infect 1990;104(2):297-302.

  46. Zavala VJ, Vado SI, Rodríguez FM, Rodríguez AE, Barrera PM, Guzmán ME. Leptospirosis anictérica en un brote epidémico de dengue en la Península de Yucatán. Rev Biomed 1998;9(2):78-83.

  47. Zavala VJ, Yu XJ, Walker DH. Unrecognized spotted fever group rickettsiosis masquerading as dengue fever in Mexico. Am J Trop Med Hyg 1996;55(2):157-159.

  48. Qiu FX, Chen QQ, Ho QY, Chen WZ, Zhao ZG, Zhao BW. The first epidemic of dengue hemorrhagic fever in the people’s Republic of China. Am J Trop Med Hyg 1991;44(4):364-370.

  49. Cobra C, Rigau-Pérez JG, Kuno G, Vorndam V. Symptoms of dengue fever in relation to host immunologic response and virus serotype, Puerto Rico, 1990-1991. Am J Epidemiol 1995;142(11):1204-1211.

  50. Halstead SB. Dengue and hemorrhagic fevers of southeast Asia. The Yale Journal of Biology and Medicine 1965;37(6):434-454.

  51. Hayes CG, Manaloto CR, González A, Ranoa CP. Dengue infections in the Philippines: clinical and virological findings in 517 hospitalized patients. Am J Trop Med Hyg 1988;39(1):110-116.

  52. Qiu FX, Gubler DJ, Liu J Ch, Chen QQ. Dengue in China: A clinical review. Bull World Health Organ 1993;71(3/4):349-359.

  53. Rigau-Pérez JG. Clinical manifestations of dengue hemorrhagic fever in Puerto Rico, 1990-1991. Pan Am J Public Health 1997;1(5):381-388.

  54. George R, Lum L. Clinical spectrum of dengue infection. En: Gubler DJ, Kuno G. Dengue and dengue hemorrhagic fever. Wallingford, UK: CAB International 1997:89-113.

  55. Nelson E, Chulajata R. Danger signs in Thai hemorrhagic fever (dengue). Tropical Pediatrics 1965;67(3):463-470.

  56. Nelson ER. Hemorrhagic fever in children in Thailand. Report of 69 cases. Tropical Pediatrics 1960;56(1):101-108.

  57. Kabra SK, Verma IC, Arora NK, Jain Y, Kaira V. Dengue hemorrhagic fever in children in Delhi. Bull World Health Organ 1992;70(1):105-108.

  58. Guzmán MG, Kourí GP, Martínez E, Bravo J, Rivero R, Soler M. Clinical and serologic study of Cuban children with dengue hemorrhagic/dengue shock syndrome (DHF/DSS). Bull Pan Am Health Organ 1987;21(3):270-279.

  59. Díaz A, Kourí GP, Guzmán MG, Lobaina L, Bravo J, Ruiz A et al. Cuadro clínico de la fiebre hemorrágica del dengue/síndrome de choque del dengue en el adulto. Bol Of Sanit Panam 1988;104(6):560-571.

  60. Kourí GP, Guzmán MG, Bravo JR, Triana C. Dengue hemorrhagic fever/dengue shock syndrome: lessons from the Cuban epidemic, 1981. Bull World Health Organ 1989;67(4):375-380.

  61. Valdés L, Guzmán MG, Kourí GP, Delgado J, Carbonell I, Cabrera MV et al. La epidemiología del dengue y el dengue hemorrágico en Santiago de Cuba, 1997. Rev Panam Salud Publica 1999;6(1):16-24.

  62. Guzmán MG, Vázquez S, Martínez E, Alvarez M, Rodríguez R, Kourí G et al. Dengue en Nicaragua, 1994: reintroducción del serotipo 3 en las Américas. Bol Oficina Sanit Panam 1996;121(2):103-110.

  63. Rigau-Pérez JG, Bonilla GL. An evaluation of modified case definitions for the detection of dengue hemorrhagic fever. Puerto Rico Association of Epidemiologists. P R Health Sci J 1999;18(4):347-352.

  64. Halstead S. Is there an inapparent dengue explosion? Lancet 1999;353:1100.

  65. Reynes JM, Laurent A, Deubel V, Telliam E, Moreau JP. The first epidemic of dengue hemorrhagic fever in French Guiana. Am J Trop Med Hyg 1994;51(5):545-553.




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