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Colegio de Medicina Interna de México.

2016, Number 3

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Med Int Mex 2016; 32 (3)

Endothelial dysfunction assessed by photoplethysmography in patients with diabetes mellitus type 2

Castillo-Martínez L, Ortiz-Suárez G, Montañez-Orozco Á, Orea-Tejeda A, Keirns-Davis C, Dávila-Radilla F, Alcalá-Dávila E, Kauffman-Ortega E, Infante-Vázquez O, Martínez-Memije R

Language: Spanish
References: 17
Page: 296-306
PDF size: 715.69 Kb.


ABSTRACT

Background: Diabetes mellitus (DM) reduces life expectancy by a third, principally because of cardiovascular disease and endothelial dysfunction are considered the first manifestations of vascular disease. Photoplethysmography is a non-invasive technique to evaluate endothelial dysfunction based on the emission of infra-red light on the skin.
Objetive: To evaluate endothelial function by photoplethysmography in patients with type 2 DM without evidence of vascular disease.
Material and Method: A cross-sectional study of patients with and without DM was undertaken. Endothelial function was evaluated using photoplethysmographic waves taking into consideration the shape of the curve and time of maximum amplitude/total time of the curve (TMA/TT) before and after ischemia induced by arterial obstruction.
Results: In 174 subjects included, a greater basal TMA/TT index was found in diabetics, even after adjusting for age, hypertension, dyslipidemia and hypothyroidism. The percentage of change in amplitude post-ischemia compared to basal value was diminished in diabetics (p=0.030). Persons with diabetes, with and without endothelial dysfunction, had comparable HbA1c concentrations; but diabetics with endothelial dysfunction had lower serum concentration of HDL-C (p=0.05).
Conclusion: More endothelial dysfunction was found in patients with diabetes. While the control of diabetes did not influence endothelial dysfunction, it was associated with lower HDL cholesterol.


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