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ISSN 1561-2988 (Print)

2015, Number 4

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Rev Cubana Farm 2015; 49 (4)

Evaluation of the effectiveness of abiraterone in treatment of metastatic prostate cáncer

Selvi SP, Titos AJC, Manresa RN, de la Rubia OJE

Language: Spanish
References: 22
Page: 673-681
PDF size: 161.25 Kb.


ABSTRACT

Objectives: to study the efficacy and safety profile of abiraterone in clinical practice to treat patients with hormone-resistant metastatic prostate cancer.
Methods: retrospective and descriptive study of patients who were diagnosed with metastatic prostate cancer and were treated with abiraterone since February 2012 to April 2013. The studied variables were gender, age, level of Eastern Cooperative Oncology Group (ECOG) scale, prior treatment with docetaxel, prostate specific antigen (PSA), progression-free survival (PFS). Data sources included medical records, the Savac® prescription and the Farmis-Oncofarm® pharmaceutical validation programs.
Results: twenty-four patients were included, with average age of 70 years. The ECOG performance status was less than 2 in 58,3% of patients whereas 41,7% of the patients showed ECOG equal to 2 or higher. The PSA decreased by 50% or more its basal value in 52% of the patients. As regards to PFS, the median was 166 days (5,5 months) in progression-free survival. In patients with ECOG ≤ 2, the median PFS was 231 days (7,7 months), whereas for patients with ECOG › 2,it was 106 days (3,5 months). Abiraterone has fewer side effects, so it may be considered a safe drug, although some are significant.
Conclusions: the results obtained in our clinical practice differ from the ones obtained in the pivotal trials . Increased progression-free survival was observed in patients with an ECOG ≤ 1 or less, and in those who had never received prior chemotherapy.


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