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2015, Number 4

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Rev Cubana Invest Bioméd 2015; 34 (4)

Oxidative stress and urinary albumin excretion in type 2 diabetics

Céspedes MEM, Riverón FG, Alonso RC, Cabrera Pérez-Sanz E, Suárez CN, Rodríguez OKM

Language: Spanish
References: 30
Page: 347-356
PDF size: 201.13 Kb.


ABSTRACT

Introduction: microalbuminuria is associated to an increase of cardiovascular mortality in diabetic patients and acts as a vascular risk indicator in these patients. The oxidative stress affects the function of the endothelium and favors the vascular damage.
Objective: to analyze whether the microalbuminuria is associated with oxidative stress indicators in type 2 diabetic patient.
Methods: in 94 type 2 diabetic patients, who went to the endocrinology service in “Hermanos Ameijeiras” hospital, their urinary albumin excretion, lipid profile, thiobarbituric acid-reactive products, protein oxidation and the activity of extracellular dismutase superoxide and catalase were all quantitated. Data on the presence of microalbuminuria and glycemic control were stratified.
Results: in patients with high blood glucose concentration on fasting, 48.27 % presented with microalbuminuria. The activity of catalase was greater in diabetics with glucose on fasting in the reference range and microalbuminuria. There was association between the activity of this enzyme and microalbuminuria (r= 0,434; p= 0.008). The activity of dismutase superoxide tends to be lower in diabetics with altered glucose on fasting and with microalbuminuria. As to the glycemic control (HbA1c), there were no differences in presence or absence of microalbuminuria, although the lower oxidative damage to biomolecules is observed in controlled patients without microalbuminuria.
Conclusions: the study of the catalase activity may offer supplementary criteria about the evaluation of urinary albumin excretion and the vascular risk in type 2 diabetic patient.


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