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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2005, Number 5

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Rev Invest Clin 2005; 57 (5)

Growth hormone and prolactin in maternal plasma and amniotic fluid during normal gestation

Hernández-Andrade E, Villanueva-Díaz C, Ahued-Ahued JR

Language: Spanish
References: 19
Page: 671-675
PDF size: 145.34 Kb.


ABSTRACT

Objective. To measure the concentration of human growth hormone (GH) and prolactin (PRL) in maternal plasma (MP) and amniotic fluid (AF) during gestation and to evaluate their correlation. Methods. HC and PRL were measured by radioimmunoassay in 60 healthy women with uncomplicated singleton pregnancies at 16-36 weeks of gestation (WG). Trends of both hormones were estimated throughout pregnancy. The correlation of either hormone measured in different fluids was also estimated. Results. GH in AF (AF-GH) decreased significantly throughout pregnancy; (AF-GH = 21.32 - 0.54 X WG, r = -0.72 [95% confidence intervals (95% CI) -0.57-0.82], p = 0.001), and increased in MP (MP-GH); (MP-GH = 2.73 +0.11 X WG, r = 0.45 [95% CI, 0.21-0.63] p = 0.05). The correlation between MP-GH and AF-GH was, (AF-GH = 16.28 - 1.54 x - M-PGH, r = -0.47 [95% CI, -0.64 - -0.21]; p = 0.01). PRL values did not show significant differences neither in AF (AF-PRL / WG, r = 0.06, p = 0.6) nor in MP (MP-PRL / WG, r = 0.25, p = 0.14) during pregnancy, being AF-PRL (mean 151.3 ng/mL, SD 34.2 ng/mL) significantly higher than MP-PRL (mean 119.3 ng/mL, SD 55.4 ng/mL) (p = 0.006) in all the studied period. Conclusion. AF-GH and MP-GH showed a significant negative correlation during pregnancy. PRL measured in AF and PM did not show changes throughout gestation being AF-PRL significantly higher than MP-PRL.


REFERENCES

  1. Speroff L, Glass R, Kase N. Endocrinología del embarazo. En: Speroff L, Glass R, Kase N, editores. Endocrinología ginecológica e infertilidad. 1a. Ed. Barcelona: Waverly Hispánica, S.A.-S.L; 2000, pp. 275-335.

  2. Evain-Brion D, Malassine A. Human placenta as an endocrine organ. Growth Horm IGF Res 2003; 13: S34-S7.

  3. Frankenne F, Closset J, Gomez F, Scippo ML, Smal J, Hennen G. The physiology of growth hormones (GHs) in pregnant wom-en and partial characterization of the placental GH variant. J Clin Endocrinol Metab 1988; 66: 1171-80.

  4. Freeman ME, Kanyicska B, Lerant A, Nagy G. Prolactin: structure, function, and regulation of secretion. Physiol Rev 2000; 80: 1523-31.

  5. De Santis M, Cavaliere AF, Noia G, Másini L, Menini E, Caruso A. Acute recurrent polyhydramnios and amniotic prolactin. Prenat Diagn 2000; 20: 347-8.

  6. Ron M, Beller U, Ori J, Ben-David M, Palti Z. Maternal and fetal serum prolactin levels in cases of premature rupture of membranes. Acta Obstet Gynecol Scand 1983; 62: 37-8.

  7. Mirlesse V, Frankenne F, Alsat E, Poncelet M, Hennen G, Evain-Brion D. Placental growth hormone levels in normal pregnancy and in pregnancies with intrauterine growth retardation. Pediatr Res 1993; 34: 439-42.

  8. Alsat E, Guibourdenche J, Couturier A, Evain-Brion D. Phys-iological role of human placental growth hormone. Mol Cell Endocrinol 1998; 140: 121-7.

  9. Bauer MK, Harding JE, Bassett NS, Breier BH, Oliver MH, Gal-laher BH, Evans PC, Woodall SM, Gluckman PD. Fetal growth and placental function. Mol Cell Endocrinol 1998; 140: 115-20.

  10. Evain-Brion D, Alsat E, Igout A, Frankenne F, Hennen G. Placental growth hormone variant: assay and clinical aspects. Acta Paediat 1994; 399: 49-51.

  11. McIntyre HD, Serek R, Crane DI, Veveris-Lowe T, Parry A, Johnson S, Leung KC, Ho KK, Bougassa M, Hennen G, Igout A, Chan FY, Cowley D, Cotterill A, Barnard R. Placental growth hormone (GH), GH-binding protein, and insulin-like growth factor axis in normal, growth-retarded, and diabetic pregnancies: correlations with fetal growth. J Clin Endocrinol Metab 2000; 5: 1143–50.

  12. Chowen JA, Evain-Brion D, Pozo J, Alsat E, Garcia-Segura LM, Argente J. Decreased expression of placental growth hormone in intrauterine growth retardation. Pediatr Res 1996; 39: 736-9.

  13. Bona G, Aquili C, Ravanini P, Gallina MR, Cigolotti AC, Zaffaroni M, Paniccia P, Mussa F. Growth hormone, insulin-like growth factor-I and somatostatin in human fetus, newborn, mother plasma and amniotic fluid. Panminerva Med 1994; 36: 5-12.

  14. Casanueva E, Ripoll C, Meza-Camacho C, Coutino B, Ramirez-Peredo J, Parra A. Possible interplay between vitamin C deficiency and prolactin in pregnant women with premature rupture of membranes: facts and hypothesis. Med Hypotheses 2005; 64: 241-7.

  15. Fataneh A, Gayle D, Wang S, Ross M. Intramembranous amniotic fluid (AF) absorption: gene expression of prolactin (PRL) receptor nephrin. Am J Obstet Gynecol 2003; 189: S197.

  16. Maaskant RA, Boeic L, Gilger S, Bryant-Greenwood GD. Peripartal distribution and expression of the human prolactin receptor in the fetal membranes and placenta. Gynecol Invest 1995; 2: 396.

  17. Parra A, Ramírez-Peredo J. The possible role of prolactin in preeclampsia: 2001, a hypothesis revisited a quarter of century later. Med Hypotheses 2002; 59: 378-84.

  18. Shaarawy M, El Minawi AM. Prolactin and calcitropic hormones in preterm premature rupture of membranes. Int J Gynaecol Obstet 2004; 84: 200-7.

  19. Bethea CL, Gravett MG, Sadowsky DW, Haluska GJ, Axthelm MK, Novy MJ. Amniotic fluid prolactin is decreased by exper-imental intrauterine infection or interleukin-1beta infusion but not via prostaglandins in pregnant rhesus macaques. Biol Reprod 1998; 58: 1385-93.




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