medigraphic.com
ISSN 0185-6014 (Print)
Órgano oficial de difusión de la Federación Mexicana de Patología Clínica, AC y de la Asociación Latinoamericana de Patología Clínica/Medicina de Laboratorio

2016, Number 1

<< Back Next >>

Rev Mex Patol Clin Med Lab 2016; 63 (1)

Delayed skin reaction with candidin in hospitalized children

López-Martínez R, Bazán-Mora E, Méndez-Tovar LJ

Language: Spanish
References: 18
Page: 19-23
PDF size: 240.32 Kb.


ABSTRACT

Introduction: Candida is a fungal pathogen found as part of the normal flora of the human skin and mucous membranes. Candida colonization takes place at an early age, which stimulates the production of antibodies and sensitized cells to limit or eliminate the infectious process. The candidin antigen is commonly used for intradermal tests of delayed hypersensitivity. Objective: To determine the frequency of positive skin tests to candidin and its relation with the characteristics of hospitalized pediatric patients. Material and methods: We performed a retrospective review of 450 medical records of patients with a documented skin test to candidin. We analyzed the relationship with variables such as gender, age, nutritional status, place of origin, hemoglobin levels and white blood cell count. Results: Positive skin tests to candidin occurred in 124 individuals (27.55%); 74 male (59.68%) and 50 female (40.32%). Overall, the frequency was 20.8%, 36.6% and 51.1% in the ranges of zero to five, six to 10 and 11 to 16 years, respectively. There were no significant differences between the other variables analyzed. Conclusions: The frequency of positive skin test results was slightly higher in the study population than in patients with any immunosuppression. We suggest the application of candidin skin tests to assess the cell-mediated immune response.


REFERENCES

  1. Waggoner-Fountain LA, Walker MW, Hollis RJ, Pfaller MA, Ferguson JE 2nd, Wenzel RP et al. Vertical and horizontal transmission of unique Candida species to premature newborns. Clin Inf Dis. 1996; 22 (5): 803-808.

  2. Caballero-Trejo A, Aguirre-Morales CE, González-González GM, Cortés-Palma D, Miranda-Novales MG. Colonización por Candida en una unidad de cuidados intensivos neonatales. Rev Med Inst Mex Seguro Soc. 2014; 52 (Supl 2): S16-S23.

  3. Martínez-Garnica DE, Jiménez-Jiménez M, Ramírez-Guerrero C, López-Martínez B. Evaluación de la utilidad clínica de la prueba ELISA de detección de Ag manano de Candida para el diagnóstico de la candidiasis invasiva en pacientes pediátricos. Rev Latinoam Patol Clin. 2015; 62 (2): 81-85.

  4. Vartivarian S, Smith CB. Pathogenesis, host resistance and predisposing factors. In: Bodey GP, editor. Candidiasis. Pathogenesis, diagnosis and treatment. New York: Raven Press; 1993. pp. 59-84.

  5. Bonilla ALA, Vera PA, Benuto ARE, Moreno CC. Candidina intralesional en el tratamiento de verrugas víricas recalcitrantes. Dermatologia. 2004; 48: 307-310.

  6. Bonilla L, Vera A, Benuto R. Candidina intralesional en el tratamiento de las verrugas planas en la cara. Piel. 2005; 20 (3): 112-114.

  7. Cruz PDMC, Padilla DMC, Alonzo-Romero PL, Palma RA, Peralta PML. Tratamiento con candidina de pacientes con verrugas vulgares resistentes. Dermatología Rev Mex. 2011; 55 (1): 9-16.

  8. Rosenberg EW, Skinner RB Jr. Immunotherapy of alopecia areata with intralesional Candida antigen. Pediatr Dermatol. 2006; 23 (3): 299.

  9. Lee MK, Cho EB, Park EJ, Kim KH, Kim KJ. A study of nail disorders en children. Korean J Med Mycol. 2014; 19 (4): 93-104.

  10. Gómez F. Desnutrición. Salud Pública Mex. 2003; 45 (4): 576-582.

  11. McMurray DN, Watson RR, Reyes MA. Effect of renutrition on humoral and cell-mediated immunity in severely malnourished children. Am J Clin Nutr; 1981; 34 (10): 2117-2126.

  12. Dorantes S. Problemas hematológicos en pediatría. Ediciones Médicas del Hospital Infantil de México Federico Gómez; 1997.

  13. Tschudy MM, Arcara KM. Manual Harriet Lane de pediatría. 19.ª edición. Barcelona, España: Elsevier; 2013. p. 1133.

  14. Sánchez-Alemán MA, Araiza J, Bonifaz A. Aislamiento y caracterización de cepas silvestres Sporothrix schenckii e investigación de reactores a la esporotricina. Gac Méd Méx. 2004; 140 (5): 507-512.

  15. Ramos R, Mendoza M, Pérez C, Díaz E. Detección de Candida en cavidad bucal en un grupo de niños eutróficos y desnutridos. Acta Odontol Venez. 2009; 47 (4): 44-55.

  16. Costa NM, Albuquerque Md, Lins JB, Alvares-Junior JT, Stefani MM. Delayed-type hypersensitivity skin test responses to PPD and other antigens among BCG-vaccinated HIV-1-infected and healthy children and adolescents. Rev Soc Bras Med Trop. 2011; 44 (5): 542-545.

  17. Orriols R, Morell F, Fité E, Ruiz J, Tornos C, Sanz R, Morera J. Delayed skin reaction in a group of 400 hospital patients: control study (author’s transl). Med Clin (Barc). 1981; 77 (6): 240-242.

  18. Gaitán-Cepeda LA, Sánchez-Vargas LO, Pavia-Ruz N, Muñoz-Hernández R, Villegas-Ham J, Caballos-Salobreña A. Candida bucal en niños mexicanos, desnutrición o marginación social. Rev Panam Salud Pública. 2012; 31 (1): 48-53.




2020     |     www.medigraphic.com