2005, Number 09
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Ginecol Obstet Mex 2005; 73 (09)
Endometriosis. Is it a problem of the immunological signs?
Hernández Qt, Hernández Vm, Zárate Ta, Pérez Fe
Language: Spanish
References: 45
Page: 492-499
PDF size: 69.05 Kb.
ABSTRACT
Endometriosis syndrome affects 5% to 35% of women in reproductive age. Many theories have been suggested, but the true importance is the survival mechanism of endometriotic tissue, which seems to be related to a defect of the immunological vigilance from macrophages, which are responsible for secretion of a variety of biochemical substances such as cytokines, prostaglandins and growth factors, which through different ways stimulates the growth of the endometrial cells. This has been observed for the clear interrelation between the homeostasis of the body and the evident association of the hormonal factors with the processes of the immunological system, in whose field many steps are unknown.
REFERENCES
Rojas PG, Díaz AD, De la Rosa AE, Barroso VG, Kably AA. Endometriosis, análisis del hallazgo laparoscópico en el Hospital ABC. Ginecol Obstet Mex 1995;63:401-5.
Gómez AE, Gorozpe JI. Endometriosis. Mecanismos potenciales de esterilidad. Esquema inductor en pacientes con endometriosis. Revisión y reflexiones. Ginecol Obstet Mex 1999;67(2):58-63.
Sensky TE, Liu DT. Endometriosis: associations with menorrhagia, infertility, and oral contraceptives. Int J Gynaecol Obstet 1980;17(6):5736.
Donnez J, Squifflet J, Pirard C, et al. The efficacy of medical and surgical treatment of endometriosis-associated infertility and pelvic pain. Gynecol Obstet Invest 2002;54(Suppl 1):2-7.
Yoshida S, Harada T, Iwabe T, Terakawaw N. Laparoscopic surgery for the management of ovarian endometrioma. Gynecol Obstet Invest 2002;54:24-29.
Zárate TA, Villalobos M, Hernández-Valencia M. El enigma de la endometriosis. Rev Fac Med UNAM 1995;38:31-34.
Oosterlynck DJ, Cornillie FJ, Waer M, Vandeputte M, Koninckx PR. Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium. Fertil Steril 1991;56(1):45-51.
Gazvani R, Templeton A. Peritoneal environment, cytokines and angiogenesis in the pathophysiology of endometriosis. Reproduction 2002;123:217-26.
Bedaiwy MA, Falcone T. Peritoneal fluid environment in endometriosis: Clinicopathological implications. Minerva Ginecol 2003;55:333-45.
Kyama MC, Debrocks, Mwenda JM, D’Hooghe TM. Potential involvement of the immune system in the development of endometriosis. Reprod Biol Endocrinol 2003;1:123.
Braun DP, Dmowski WP. Endometriosis: Abnormal endometrium and dysfunctional immune response. Curr Opin Obstet Gynecol 1998;10:365-9.
De Placido G, Aviggi C, Di Palma G, et al. Serum concentrations of soluble human leukocytes class I antigen and of the soluble intercellular adhesion molecule-1 in endometriosis: relationship with stage and non-pigmented peritoneal lesions. Hum Reprod 1998;13:3206-10.
Semino C, Barocci S, Semino A, et al. Role of major histocompatibility complex class I expression and natural killer-like T cells in the genetic control of endometriosis. Fertil Steril 1995;64:909-16.
Baxevanis CN, Gritzapis AD, Papamichail M. In vivo antitumor activity of NKT cells actived by the combination of IL-12 and IL-18. J Immunol 2003;171:2953-9.
Heinig J, Von Otte S, Greb RR, Kiesel L. Molecular mechanisms contributing to the pathogenesis of endometriosis. Gynecol Endocrinol 2002;16:493-504.
Hernández GCA, Tlapanco BR, Ramos PC, et al. Endometriosis y abatimiento de las características de la respuesta inmunológica citotóxica. Ginecol Obstet Mex 2003;71:559-74.
Somigliana E, Vigano P, Gaffuri B, et al. Endometrial stromal cells as a source of intercellular adhesion molecule (ICAM)-1 molecules. Hum Reprod 1996;11:1190-94.
Vigano P, Gaffuri B, Somigliana E, et al. Expression of intercellular adhesion molecule (ICAM)-1 mRNA and protein is enhanced in endometriosis versus endometrial stromal cells in culture. Mol Hum Reprod 1998;4:1150-6.
Garcia-Velasco TA, Arici A, Zreik TG, Naftolin F, Mor G. Macrophage derived growth factors modulates fas ligand expression in cultures endometrial stromal cells: a role in endometriosis. Mol Hum Reprod 1999;5:642-50.
Van Langendonckt A, Casanas-Roux F, Donnez J. Oxidative stress and peritoneal endometriosis. Fertil Steril 2002;77:861-70.
Donnez J, Langendonckt A, Casanas RF, et al. Current thinking on the pathogenesis of endometriosis. Gynecol Obstet Invest 2002;54:52-62.
Abrao MS, Podgaecs S, Filho BM, et al. The use of biochemical markers in the diagnosis of pelvic endometriosis. Hum Reprod 1997;12:2523-7.
Zeitoun K, Takayama K, Sasano H. Deficient 17 beta-hydroxysteroid dehydrogenase type 2 expression in endometriosis: failure to metabolize 17 beta-estradiol. J Clin Endocrinol Metab 1998;83:4474-80.
Noble LS, Takayama K, Zeitoun KM. Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cells. J Clin Endocrinol Metab 1997;82:600-6.
Vignali M, Infantino M, Matrone R, Chiodo I, et al. Endometriosis: novel etiopathogenetic concepts and clinical perspectives. Fertil Steril 2002;78:655-78.
Braun DP, Dmowski WP. Endometriosis: abnormal endometrium and dysfunctional immune response. Curr Opin Obstet Gynecol 1998;10:365-9.
Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other diseases. Nat Med 1995;1:27-31.
Clayton RD, Duffy SR, Wilkinson N, Garry R, Jackson AM. Anti-proliferative effect of mycobacteria, IFN-gamma and TNF-alpha on primary cultures derived from endometrial stroma: possible relevance to endometriosis? Am J Reprod Immunol 2004;51:63-70.
Kitawaki J, Koshiba H, Kitaoka Y, et al. Interferon-gamma gene dinucleotide (CA) repeat and interleukin-4 promoter region (-590C/T) polymorphisms in Japanese patients with endometriosis. Hum Reprod 2004;19:1765-9.
McLaren J, Prentice A, Chamock-Jones DS, Smith SK. Vascular endothelial growth factor (VEGF) concentrations are elevated in peritoneal fluid of women with endometriosis. Hum Reprod 1996;11:220-3.
McLaren J. Vascular endothelial growth factor and endometriotic angionesis. Hum Reprod Update 2000;6:45-55.
Van der Linden PJ, de Geoij AF, Dunselman GA. Expression of integrins and E-cadherin in cells from menstrual effluent, endometrium, peritoneal fluid, peritoneum, and endometriosis. Fertil Steril 1994;61:85-90.
Regidor PA, Vogel C, Regidor M. Schindler AE. Expression pattern of integrin adhesion molecules in endometriosis and human endometrium. Hum Reprod Update 1998;4:710-8.
Dechaud H, Witz CA, Montoya-Rodríguez IA. Mesothelial cell-associated hyaluronic acid promotes adhesion of endometrial cells to mesothelium. Fertil Steril 2001;76:1012-8.
Levine Z, Efstathiou JA, Sampson DA. Angiogenesis inhibitors suppress endometriosis in a murine model. J Soc Gynecol lnvestig 2002;9:264-7.
Sharpe-Timms KL, Zimmer RL, Ricke EA, Piva M, Horowitz GM. Endometriotic haptoglobin binds to peritoneal macrophages and alters their function in women with endometriosis. Fertil Steril 2002;78:810-9.
Sharpe-Timms KL, Piva M, Ricke EA, Surewickz K, Zhang YL, Zimmer RL. Endometriotic synthesizes and secrete a haptoglobin-like protein. Biol Reprod 1998;58:988-94.
Santanam N, Murphy AA, Parthasarathy S. Macrophages, oxidation, and endometriosis. Ann NY Acad Sci 2001;955:183-200.
Pauwels A, Schepens PJ, D’Hooghe T, et al. The risks of endometriosis and exposure to dioxins and polychlorinated biphenyls: a case-control study of infertile women. Hum Reprod 2001;16:2050-5.
Eskenazi B, Mocarelli P, Warner M. Serum dioxin concentrations and endometriosis: a cohort study in Seveso, Italy. Environ Health Perspect 2002;110:629-34.
Stokstad E. Pollution gets personal. Science 2004;304:1892-4.
García-Velasco JA, Arici A. Apoptosis and the pathogenesis of endometriosis. Semin Reprod Med 2003;21:165-72.
García-Velasco JA, Arici A, Zreik T, Naftolin F, Mor G. Macrophage derived growth factors modulate Fas ligand expression in cultured endometrial stromal cells: a role in endometriosis. Mol Hum Reprod 1999;5:642-50.
Taylor HS, Bagot C, Kardana A. HOX gene expression is altered in the endometrium of women with endometriosis. Hum Reprod 1999;14:1328-31.
King EA, Critchley ODH, Kelly WR. Innate immune defenses in the human endometrium. Reprod Biol Endocrinol 2003;1:116-9.