2015, Number 3
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Rev Cub Med Mil 2015; 44 (3)
Predictors of mortality due to intracerebral hemorrhage during the acute period
Pérez GAR, García MA, Sosa AEF, Padrón VF
Language: Spanish
References: 31
Page: 277-288
PDF size: 141.67 Kb.
ABSTRACT
Introduction: in Cuba cerebrovascular disease occupies the third cause of death, followed by cardiovascular diseases and neoplasms and it is the fifth leading cause of years of healthy life lost. Inside the cerebrovascular disease, intracerebral hemorrhage is the major complication.
Objective: determine the factors associated with short-term mortality of intracerebral hemorrhage.
Method: a cohort-retrospective and analytical study was conducted with intracerebral hemorrhage patients admitted in hospital emergency and therapies
services. Clinical, demographic and imaging factors were considered for the hypothetical forecasts of death from intracerebral hemorrhage.
Results: the age group 70-79 has higher mortality (76.2%) and the highest number of cases of intracerebral hemorrhage (59 patients). 60% of patients taking
anticoagulants prior to intracerebral hemorrhage, died; while 67% of non consumers survived. The relationship between intracerebral hemorrhage and ischemic heart disease is independently associated to death event (p= 0.00), while patients with respiratory infection had the highest proportion with deceased patients (73.1%).
On the other hand, patients who arrived unconscious and urinary incontinence were directly related to mortality (77.5%) and (69.1%) respectively. Those who had ventricular hematoma extension and volume higher than 50 ml presented 8 and 13 times more probabilities to die than the others, respectively.
Conclusions: the mortality predictors of intracerebral hemorrhage were: use of oral anticoagulants, ischemic heart disease, the presence of respiratory infection, unconscious on admission, the presence of urinary incontinence, ventricular extension of the hematoma and intracerebral hemorrhage with higher volume than 50 ml.
REFERENCES
Appelros P, Stegmayr B, Terent A. Sex differences in stroke epidemiology: a systematic review. Stroke. 2009;40(4):1082-90.
Buergo Zuaznábar MA, Fernández Concepción O. Guías de práctica clínica. Enfermedad cerebrovascular. La Habana: Editorial Ciencias Médicas. 2009.
Ropper AH, Brown RH. Adams and victor's principles of neurology. 9 ed. Barcelona: McGraw-Hill. 2009.
Richard F Keep, YaHua, Guohua Xi. Hemorrhage intracerebral. Lancet Neurol. 2012;11:720-31.
Jaffe J, Alkhawam L, Du H, Tobin K, O'Leary J, Pollock G, et al. Outcome predictors and spectrum of treatment eligibility with prospective protocolized management of intracerebral hemorrhage. Neurosurgery. 2009;64(3):436-45.
Joyce S Balami, Alastair M Buchan. Complications of intracerebral haemorrhage. Lancet Neurol [Internet]. 2012 [citado 13 Jul 2011];11:101-18. Disponible en: http://www.intramed.net/contenidover.asp?contenidoID=74051
Alessandro Biffi, Christopher D Anderson, Jeremias M Jagiella, Helena Schmidt, Brett Kissela, Björn M Hansen, et al. APOE genotype and extent of bleeding and outcome in lobar intracerebral haemorrhage: a genetic association study. Lancet Neurology. 2011;10(8):702-9.
González Zaldívar A, Gómez Viera N, Álvarez Santana R, Ávila Padrón Y. Hemorragia intracerebral. Estudio de 349 autopsias en el Hospital Clinicoquirúrgico "Hermanos Ameijeiras". Rev Cubana Med [Internet]. 2007 [citado 13 Jul 2011];46(2)1-7. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034- 75232007000200002&lng=es
Delgado Gutiérrez D, García Moreira T, Sotolongo Calderón JA, López Pardo C, Perurena Cardounell L, Hernández Rodríguez TE. Valor predictivo del comando volumen en la hemorragia intraparenquimatosa por hipertensión arterial. Rev Cubana Med Mil [Internet]. 2003 [citado 13 Jul 2011];32(4). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0138- 65572003000400007&lng=es&nrm=iso&tlng=es
Mortalidad por enfermedades cerebrovasculares en mayores de 15 años en el Policlínico Docente "Manuel Pity Fajardo" del municipio Guane. Rev Cubana Med Gen Integr. 1999;15(3):1-6.
Lubín AR, César MF, Mailén MF, Mireile MS. Ictus hemorrágico. Comportamiento epidemiológico en el Hospital Provincial Clinicoquirúrgico "Celia Sánchez Manduley" Manzanillo - Granma. Rev cubana med. 2002;41(1):1-6.
Aguilera Pacheco OR y González Vidal D. Factores pronósticos en la hemorragia cerebral intraparenquimatosa en el Hospital Provincial Docente Clinicoquirúrgico "Saturnino Lora Torres", Santiago de Cuba. MEDISAN Santiago de Cuba. 2012;16(1):4-6.
Kalita J, Misra UK, Vajpeyee A, Phadke RV, Handique A, Salwani V. Brain herniations in patients with intracerebral hemorrhage. Acta Neurol Scand. 2009;119(4):254-60.
Kumar MA, Rost NS, Snider RW, Chanderraj R, Greenberg SM, Smith EE, et al. Anemia and hematoma volume in acute intracerebral hemorrhage. Crit Care Med. 2009;37(4):1442-7.
Wasay M,Yousuf A, Lal D, Awan S. Predictors of the intracerebral hemorrhage volume in hypertensive patients. Cerebrovasc Dis Extra. 2011;1(1):1-5.
Kim KH. Predictors of 30-day mortality and 90-day functional recovery after primary intracerebral hemorrhage: hospital based multivariate analysis in 585 patients. J Korean Neurosurg Soc. 2009;45(6):341-9.
Toyoda K, Yasaka M, Nagata K, Nagao T, Gotoh J, Sakamoto T, et al. Antithrombotic therapy influences location, enlargement, and mortality from intracerebral hemorrhage. Cerebrovasc Dis. 2009;27(2):151-9.
Franke CL, van Swieten JC, Algra A, van Gijn J.Prognostic factors in patients with intracerebral haematoma.J Neurol Neurosurg Psychiatry. 1992;55(8):653-7.
Zorrilla JP, Sousa L, Loli P, Romano L, Espadaro E, Castellino G, et al. Variables predictivas de letalidad y rendimiento de la escala ReC-HPC en hemorragia intracerebral primaria en pacientes anticoagulados. Neurol Arg. 2011;3(2):94-9.
Patel AD, Tan MK, Angaran P, Bell AD, Berall M, Bucci C, et al. Risk Stratification and Stroke Prevention Therapy Care Gaps in Canadian Atrial Fibrillation Patients (from the Co-ordinated National Network to Engage Physicians in the Care and Treatment of Patients With Atrial Fibrillation Chart Audit). Am J Cardiol [Internet]. 2015[citado 6 Mar 2015];115(5):641-6. doi: 10.1016/j.amjcard.2014.12.022. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/25727083
Lauffenburger JC, Farley JF, Gehi AK, Rhoney DH, Brookhart MA, Fang G. Factors Driving Anticoagulant Selection in Patients With Atrial Fibrillation in the United States. Am J Cardiol [Internet]. 2015 [citado: 15 de enero de 2015];115(8):1095-101. doi : 10.1016/j.amjcard.2015.01.539. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/25724781
Harper P, Young L, Merriman E. Bleeding risk with dabigatran in the frail elderly. N Engl J Med [Internet]. 2012 [citado: 15 de enero de 2015];366:864-6. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/22375994
Adria A, Elizabet S, Miguel B. Factores de riesgo en la enfermedad cerebrovascular aguda: estudio comparativo entre el infarto y la hemorragia cerebral en 1.702 pacientes. Unitat de Patología Vascular Cerebral. Medclin (Barc) 2001;116:89-91.
Arboix A.Hemorragias en lóbulos cerebrales: Estudio de 97 pacientes. Med Clin (Barc). 2005;124(19):130-2.
Flaherty ML, Tao H, Haverbusch M, Sekar P, Kleindorfer D, Kissela B, et al. Warfarin use leads tolarger intracerebral hematomas. Neurology. 2008;71:1084-9.
Siddiqui FM, Bekker SV, Qureshi AI. Neuroimaging of hemorrhage and vascular defects. Neurotherapeutics. 2011;8(1):28-38.
Dowlatshahi D, Smith EE, Flaherty ML, Ali M, Lyden P, Demchuk AM; VISTA Collaborators. Small intracerebral haemorrhages are associated with less haematoma expansion and better outcomes. Int J Stroke. 2011;6:201-206.
Scherle Matamoros CE, Pérez Néllar J, Roselló Silva H. Hemorragia intracerebral espontánea. Rev Cubana Med [Internet]. 2007 [citado 13 Jul 2011];46(4):1-5. Disponible en: http://bvs.sld.cu/revistas/med/vol46_4_07/med08407.html
Barrios Fuentes PJ, Bernal Muñoz JL, Osorio Pagola MF, Ortega Arvelay A, Caneiro González LT. Hallazgos tomográficos y mortalidad en pacientes con hemorragias intracerebrales no traumáticas.Medisur. 2011;9(2):88-96.
Arima H, Huang Y, Wang JG. Earlier Blood Pressure-Lowering and Greater Attenuation of Hematoma Growth in Acute Intracerebral Hemorrhage: INTERACT Pilot Phase. Stroke. 2012;43:2236-8.
Rodríguez Sánchez LA. Barreda Jorge L. Algunas variables morfométricas de imágenes tomográficas de pacientes fallecidos con hemorragias intracerebrales. MEDICIEGO 2011;17(2):1-3.